BACKGROUND AND PURPOSE: The global burden of neurological diseases exceeds 43.1%, imposing a significant burden on patients, caregivers and society. This paper presents a roadmap to reduce this burden and improve brain health (BH) in Europe. METHODS: The roadmap is based on the European Academy of Neurology's (EAN) five-pillar BH strategy: advancing a global BH approach (P1), supporting policymaking (P2), fostering research (P3), promoting education (P4), and raising awareness of prevention and treatment (P5). It reviews current efforts, collaborations and future directions aligned with the WHO Intersectoral Global Action Plan (iGAP) for Neurological Disorders and suggests future initiatives and call for action. RESULTS: P1: Support WHO-iGAP through defined action points, international collaborations, in particular, the WHO BH Unit, and the EAN Brain Health Mission. P2: Collaborate with 48 national neurological societies to promote National Brain Plans (NBPs), addressing local needs, and improving access to care. P3: Advocate for more research funding; identify determinants of BH; develop preventive measures. P4: Provide educational opportunities for neurologists, public education programs, and advocacy training, including tools to educate the public. P5: Spearhead global awareness campaigns, organize public educational activities, and train BH advocates to contribute toward sustainable and long-term public health campaigns and policy engagement. CONCLUSIONS: The paper highlights the importance of a unified approach, integrating international collaborations and local initiatives, to improve BH outcomes based on the WHO-iGAP, and support sustainable development goals, in particular SDG 3: Good Health and Well-being and SDG 4: Quality Education.

1st Department of Neurology St Anne's University Hospital and Faculty of Medicine Masaryk University Brno Czechia

Brain and Mind Research Central European Institute of Technology Masaryk University Brno Czechia

Center for Narcolepsy and Hypersomnias Professorship for Narcolepsy and Hypersomnolence Research Faculty of Health University Witten Herdecke Witten Germany

Department of Neurology and 4Brain Ghent University Hospital Ghent Belgium

Department of Neurology and Comprehensive Center of Clinical Neurosciences and Mental Health Medical University of Vienna Vienna Austria

Department of Neurology Inselspital University of Bern Bern Switzerland

Department of Pharmacology and Therapeutics University of Liverpool Liverpool UK

Department of Public Health and Primary Care Ghent University Belgium and United Nations University CRIS Bruges Belgium

Eindhoven University of Technology Eindhoven The Netherlands

ERN NMD Center for Neuromuscular Disorders of Messina Department of Clinical and Experimental Medicine University of Messina Messina Italy

European Academy of Neurology Vienna Austria

Grenoble Alpes University CHU of Grenoble Division of Neurology Grenoble institute of Neurosciences Grenoble France

Hôpitaux Universitaires de Genève Geneva Switzerland

Neurology Public Health Disability Unit and Coma Research Centre Fondazione IRCCS Istituto Neurologico C Besta Milan Italy

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