• The CPG provides key recommendations and algorithms for managing SMs, excluding mucosal melanoma and soft-tissue sarcomas. • The guideline covers diagnosis, staging, risk assessment, treatment and disease monitoring. • Technological advancements in treatment with RT are discussed with a special focus on particle therapy. • Surgical indications for open and transnasal endoscopic surgery are provided. • Neoadjuvant chemotherapy in high-grade, locally advanced SMs helps to select subjects for conservative treatments.

Clinic for Ear Nose and Throat Medicine Head and Neck Surgery University Hospital Essen Essen Germany

Department of Biomedical Sciences Humanitas University Milan Italy; Department of Medical Oncology and Hematology IRCCS Humanitas Research Hospital Milan Italy

Department of Clinical Surgical Diagnostic and Pediatric Sciences University of Pavia Pavia Italy; Radiation Oncology Unit Clinical Department National Center for Oncological Hadrontherapy Pavia Italy

Department of Comprehensive Cancer Care Masaryk Memorial Cancer Institute Brno Czechia; Department of Comprehensive Cancer Care Faculty of Medicine Masaryk University Brno Czechia

Department of Head and Neck Cancer Gustave Roussy Cancer Campus Villejuif France

Department of Head and Neck Oncology Instituto de Investigación Sanitaria del Principado de Asturias Oviedo Spain

Department of Head and Neck Surgery and Oncology Netherlands Cancer Institute Amsterdam The Netherlands; Amsterdam Center for Language and Communication University of Amsterdam Amsterdam The Netherlands; Department of Oral and Maxillofacial Surgery Amsterdam University Medical Center Amsterdam The Netherlands

Department of Head and Neck Surgery Gustave Roussy Cancer Campus Paris Saclay University Villejuif France

Department of Head and Neck Surgery Lariboisière Hospital Université Paris Cité Paris France

Department of Medical Oncology Radboud University Medical Center Nijmegen The Netherlands

Department of Otorhinolaryngology Head and Neck Surgery Erasmus MC Cancer Institute Rotterdam The Netherlands

Department of Otorhinolaryngology Head and Neck Surgery Hôpital Tenon Assistance Publique Hôpitaux de Paris Sorbonne University Paris France

Department of Otorhinolaryngology Head and Neck Surgery University Hospital of Bordeaux Bordeaux France

Department of Otorhinolaryngology Head and Neck Surgery University Hospital of Munich LMU Klinikum Munich Germany

Department of Radiation Oncology Centre François Baclesse Caen France; Laboratoire de physique Corpusculaire IN2P3 ENSICAEN CNRS UMR 6534 Normandie Université Caen France

Department of Translational Research and of New Technologies in Medicine and Surgery University of Pisa Pisa Italy

Division of Radiology Department of Medical and Surgical Specialties Radiological Sciences and Public Health University of Brescia ASST Spedali Civili Brescia Italy

Evaluative Epidemiology Unit Department of Epidemiology and Data Science Fondazione IRCCS Istituto Nazionale dei Tumori Milan Italy

Head and Neck Medical Oncology Department Fondazione IRCCS Istituto Nazionale dei Tumori di Milano Milan Italy; Department of Biomedical Sciences Humanitas University Milan Italy

Head and Neck Medical Oncology Department Fondazione IRCCS Istituto Nazionale dei Tumori di Milano Milan Italy; Department of Oncology and Hemato Oncology University of Milan Milan Italy

Otolaryngology Unit University of Padova Padua Italy

Radiation Oncology Unit Fondazione IRCCS Istituto Nazionale dei Tumori Milan Italy

Salivary Gland Cancer UK London UK

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