This study aimed to determine the paraoxonase activity and prooxidant-antioxidant balance in the brain tissue of Wistar rats following subacute treatment with selected K-oximes. Each K-oxime was administered intramuscularly (0.1 LD50/kg) twice per week for four weeks, and 7 days after the last treatment, the paraoxonase activity (PON1), the prooxidant-antioxidant balance (PAB), the levels of superoxide anion radical (O2•-), the concentration of nitrite (NO2-) and the content of free protein thiol groups in the brain homogenates were evaluated. The PON1 and PAB activity were significantly reduced in almost all oxime-treated groups (p < 0.01 and p < 0.001, respectively). The concentrations of O2•- were significantly increased in the obidoxime-, K048-, K074- and K075-treated groups (p < 0.001), while the levels of NO2- was significantly decreased in asoxime-, obidoxime-, K074 and K075-treated rats (p < 0.01, p < 0.001, respectively). The content of Thiol groups was significantly elevated in all oxime-treated groups (p < 0.001). Continuing our previously published data, these results confirmed that applied K-oximes improved the oxidative status and further harmful systemic effects of rats after subacute administration.

Biomedical Research Center University Hospital Hradec Kralove 50005 Hradec Kralove Czech Republic; Centre for Basic and Applied Research Faculty of Informatics and Management University of Hradec Kralove Rokitanskeho 62 500 03 Hradec Kralove Czech Republic; Center of Advanced Innovation Technologies VSB Technical University of Ostrava 70800 Ostrava Poruba Czech Republic

Centre for Biomedical Research Faculty of Medicine University of Banja Luka Save Mrkalja 14 78000 Banja Luka Bosnia and Herzegovina; Department of Human Genetics Faculty of Medicine University of Banja Luka Save Mrkalja 14 78000 Banja Luka Bosnia and Herzegovina

Department for Experimental Toxicology and Pharmacology National Poison Control Centre Military Medical Academy Crnotravska 17 11040 Belgrade Serbia; Medical Faculty of the Military Medical Academy University of Defence Crnotravska 17 11040 Belgrade Serbia

Department of Chemistry Faculty of Science University of Hradec Kralove Rokitanskeho 62 500 03 Hradec Kralove Czech Republic; Center of Advanced Innovation Technologies VSB Technical University of Ostrava 70800 Ostrava Poruba Czech Republic

Department of Human Genetics Faculty of Medicine University of Banja Luka Save Mrkalja 14 78000 Banja Luka Bosnia and Herzegovina

Department of Pharmacology Toxicology and Clinical Pharmacology Faculty of Medicine University of Banja Luka Save Mrkalja 14 78000 Banja Luka Bosnia and Herzegovina

Special Police Unit Ministry of Interior Trebevićka 12 A 11 030 Belgrade Serbia

University of Belgrade Faculty of Pharmacy Department of Pharmaceutical Chemistry Vojvode Stepe 450 11121 Belgrade Serbia

University of Belgrade Institute for Medical Research National Institute of the Republic of Serbia Department for Cardiovascular Research Dr Subotića 4 11 132 Belgrade Serbia

University of Belgrade Institute for Medical Research National Institute of the Republic of Serbia Group of Biomechanics Biomedical Engineering and Physics of Complex Systems Dr Subotića 4 11 000 Belgrade Serbia

Veterinary Services Center Military Health Department Crnotravska 17 11040 Belgrade Serbia

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