Eating disorders -including anorexia nervosa (AN), bulimia nervosa, and binge eating disorder-are clinically distinct but exhibit symptom overlap and diagnostic crossover. Genomic analyses have mostly examined AN. We conducted the first genomic meta-analysis of binge eating behaviour (BE; 39,279 cases, 1,227,436 controls), alongside new analyses of AN (24,223 cases, 1,243,971 controls) and its subtypes (all European ancestries). We identified six loci associated with BE, including loci associated with higher body mass index (BMI) and impulse-control behaviours. AN GWAS yielded eight loci, validating six loci. Subsequent polygenic risk score analysis demonstrated an association with AN in two East Asian ancestry cohorts. BE and AN exhibited similar positive genetic correlations with psychiatric disorders, but opposing genetic correlations with anthropometric traits. Most of the genetic signal in BE and AN was not shared with BMI. We have extended eating disorder genomics beyond AN; future work will incorporate multiple diagnoses and global ancestries.

1st Department of Psychiatry; National and Kappodistrian University of Athens ; Athens; Greece

Adolescent Health Unit 2nd Department of Pediatrics P and A Kyriakou Children's Hospital; National and Kappodistrian University of Athens ; Athens; Greece

Altrecht Eating Disorders Rintveld; Altrecht Mental Health Institute; Zeist; Utrecht; The Netherlands

Analytic and Translational Genetics Unit; Broad Institute of the Massachusetts Institute of Technology and Harvard University; Massachusetts General Hospital; Boston; Massachusetts; United States

Bioinformatics Research Centre; Aarhus University; Aarhus; Denmark

Biological Psychiatry Laboratory; McLean Hospital; Harvard Medical School; Belmont; Massachusetts; United States

Center for Applied Genomics; Children's Hospital of Philadelphia; Philadelphia; Pennsylvania; United States

Center for Eating and feeding Disorders Research Mental Health Center Ballerup; Copenhagen University Hospital Mental Health Services; Copenhagen; Denmark

Center for Genomics and Personalized Medicine; Aarhus University; Aarhus; Denmark

Center for Translational Neuro and Behavioral Sciences; University Hospital Essen University of Duisburg Essen; Essen; Northrhine Westfalia; Germany

Centre for Human Genetics; University of Marburg; Marburg; Germany

Centre for Occupational and Environmental Medicine; Region Stockholm; Stockholm; Sweden

Centre for Precision Psychiatry; University of Oslo; Oslo; Norway

Centre for Psychological Services; University of Barcelona; Barcelona; Catalonia; Spain

Centre for Research in Eating and Weight Disorders Department of Psychological Medicine; Institute of Psychiatry Psychology and Neuroscience; King's College London; London; United Kingdom

Ciber Physiopathology of Obesity and Nutrition ; Instituto de Salud Carlos III; Madrid; Spain

Clinic for Child and Adolescent Psychiatry Psychotherapy and Psychosomatics; German Red Cross Hospitals Berlin; Berlin; Germany

Clinical Psychology Program; The Chicago School Washington DC College of Clinical Psychology; Washington DC; United States

CNRS INSERM l'institut du thorax; Universite de Nantes; Nantes; France

College of Nursing; Seattle University; Seattle; Washington; United States

Department for Medical Biology; University of Split School of Medicine; Split; Croatia

Department of Adult Psychiatry; Poznan University of Medical Sciences; Poznan; Poland

Department of Biomedicine; Aarhus University; Aarhus; Denmark

Department of C and A Psychiatry; Medical University of Vienna; Vienna; Austria

Department of Cancer Epidemiology and Genetics; Masaryk Memorial Cancer Institute; Brno; Czech Republic

Department of Child and Adolescent Psychiatry Psychosomatics and Psychotherapy Center of Mental Health; University Hospital Wuerzburg; Wurzburg; Bavaria; Germany

Department of Child and Adolescent Psychiatry Psychosomatics and Psychotherapy; Ludwig Maximilians Universitat Munchen; Munich; Germany

Department of Child and Adolescent Psychiatry Psychosomatics and Psychotherapy; LVR University Clinic Essen University of Duisburg Essen; Essen; Northrhine Westfalia; Germany

Department of Child and Adolescent Psychiatry Psychosomatics and Psychotherapy; RWTH Aachen University; Aachen; Germany

Department of Child and Adolescent Psychiatry; Oberberg Fachklinik Fasanenkiez Berlin; Berlin; Germany

Department of Child and Adolescent Psychiatry; Poznan University of Medical Sciences; Poznan; Poland

Department of Clinical Educational and Health Psychology; University College London; London; United Kingdom

Department of Clinical Excellence; Equip Health; Carlsbad; California; United States

Department of Clinical Medicine; University of Copenhagen; Copenhagen; Denmark

Department of Clinical Neuroscience; Karolinska Institutet; Stockholm; Sweden

Department of Clinical Psychology Faculty for Social Sciences; Utrecht University; Utrecht; Utrecht; The Netherlands

Department of Clinical Psychology; University Hospital Bellvitge; Hospitalet del Llobregat ; Barcelona; Catalonia; Spain

Department of Clinical Science; University of Bergen; Bergen; Norway

Department of Clinical Sciences; School of Medicine and Health Sciences; University of Barcelona; Hospitalet del Llobregat ; Barcelona; Catalonia; Spain

Department of Community Family and Addiction Sciences; Texas Tech University; Lubbock; Texas; United States

Department of Community Health and Epidemiology; Dalhousie University; Halifax; Nova Scotia; Canada

Department of Emergency and Post Emergency Psychiatry; CHU University of Montpellier; Montpellier; France

Department of Environmental Epidemiology; Nofer Institute of Occupational Medicine; Lodz; Poland

Department of Epidemiology; University of North Carolina at Chapel Hill; Chapel Hill; North Carolina; United States

Department of General Practice and Primary Healthcare Faculty of Medical and Health Sciences; The University of Auckland; Auckland; New Zealand

Department of Genetic Medicine; Vanderbilt University Medical Center; Nashville; Tennessee; United States

Department of Genetics and Genomic Sciences; Icahn School of Medicine at Mount Sinai; New York; New York; United States

Department of Genetics and Genomic Sciences; Mindich Child Health and Development Institute; Friedman Brain Institute; Icahn School of Medicine at Mount Sinai; New York; New York; United States

Department of Genetics; Queensland Institute of Medical Research QIMR Berghofer Medical Research Institute; Brisbane; Queensland; Australia

Department of Genetics; University of North Carolina at Chapel Hill; Chapel Hill; North Carolina; United States

Department of Genomics Life and Brain Center; University of Bonn; Bonn; Northrhine Westfalia; Germany

Department of Health Sciences; University of Florence; Florence; Italy

Department of Medical Epidemiology and Biostatistics; Karolinska Institutet; Stockholm; Sweden

Department of Medical Genetics; University of British Columbia; Vancouver; British Columbia; Canada

Department of Medical Research; Vestre Viken Hospital Trust Barum Hospital; Gjettum; Norway

Department of Medicine Solna; Division of Rheumatology; Karolinska Institutet; Stockholm; Sweden

Department of Medicine Surgery and Dentistry Scuola Medica Salernitana ; University of Salerno; Salerno; Italy

Department of Medicine; New Jersey Medical School Rutgers University; Newark; New Jersey; United States

Department of Mental and Physical Health and Preventive Medicine; University of Campania Luigi Vanvitelli ; Naples; Italy

Department of Mental Health and Neuroscience; Queensland Institute of Medical Research QIMR Berghofer Medical Research Institute; Brisbane; Queensland; Australia

Department of Neuroscience Psychology Drug Research and Child Health ; University of Florence; Florence; Italy

Department of Neuroscience; University of Padova; Padova; Italy

Department of Nutrition and Dietetics; Harokopio University; Athens; Greece

Department of Nutrition; University of North Carolina at Chapel Hill; Chapel Hill; North Carolina; United States

Department of Pathology and Biomedical Science; University of Otago; Christchurch; New Zealand

Department of Pediatrics; University of Pennsylvania Perelman School of Medicine; Philadelphia; Pennsylvania; United States

Department of Physiology; Institute of Neuroscience and Physiology; Sahlgrenska Academy at University of Gothenburg; Gothenburg; Sweden

Department of Population Health; Queensland Institute of Medical Research QIMR Berghofer Medical Research Institute; Brisbane; Queensland; Australia

Department of Psychiatric Genetics Medical Biology Center; Poznan University of Medical Sciences; Poznan; Poland

Department of Psychiatry and Behavioral Sciences; Stanford University; Stanford; California; United States

Department of Psychiatry and Biobehavioral Sciences; University of California Los Angeles; Los Angeles; California; United States

Department of Psychiatry and Neurochemistry; Institute of Neuroscience and Physiology; University of Gothenburg; Gothenburg; Sweden

Department of Psychiatry and Psychotherapy Comprehensive Center for Clinical Neurosciences and Mental Health ; Medical University of Vienna; Vienna; Austria

Department of Psychiatry and Psychotherapy; Charite Universitatsmedizin; Berlin; Germany

Department of Psychiatry; 1st Faculty of Medicine; Charles University and General University Hospital; Prague; Czech Republic

Department of Psychiatry; Boston University Chobanian and Avedisian School of Medicine; Boston; Massachusetts; United States

Department of Psychiatry; Centre for Addiction and Mental Health; University of Toronto; Toronto; Ontario; Canada

Department of Psychiatry; Division of Psychiatric Genomics; Icahn School of Medicine at Mount Sinai; New York; New York; United States

Department of Psychiatry; ERC Pathlight; University of Maryland St Joseph Medical Center; Baltimore; Maryland; United States

Department of Psychiatry; Helsinki University Hospital; Helsinki; Finland

Department of Psychiatry; Icahn School of Medicine at Mount Sinai; New York; New York; United States

Department of Psychiatry; Ilsan Paik Hospital Inje University; Goyang; South Korea

Department of Psychiatry; Leiden University Medical Centre; Leiden; The Netherlands

Department of Psychiatry; Reinier van Arkel; s Hertogenbosch; Northern Brabant; The Netherlands

Department of Psychiatry; Rutgers University; Piscataway; New Jersey; United States

Department of Psychiatry; University of California San Diego; San Diego; California; United States

Department of Psychiatry; University of Campania Luigi Vanvitelli ; Naples; Italy

Department of Psychiatry; University of Minnesota; Minneapolis; Minnesota; United States

Department of Psychiatry; University of North Carolina at Chapel Hill; Chapel Hill; North Carolina; United States

Department of Psychiatry; University of Perugia; Perugia; Italy

Department of Psychiatry; University of Toronto; Toronto; Ontario; Canada

Department of Psychiatry; University of Wisconsin; Madison; Wisconsin; United States

Department of Psychological Medicine; Stress Psychiatry and Immunology Laboratory; Institute of Psychiatry Psychology and Neuroscience; King's College London; London; United Kingdom

Department of Psychological Medicine; University of Otago; Christchurch; New Zealand

Department of Psychology; Michigan State University; East Lansing; Michigan; United States

Department of Psychology; PROMENTA Research Centre; University of Oslo; Oslo; Norway

Department of Psychology; University of Texas; Austin; Texas; United States

Department of Psychosomatic Medicine and Psychotherapy; Hannover Medical School; Hannover; Germany

Department of Psychosomatic Medicine and Psychotherapy; University Medical Hospital Tuebingen; Tuebingen; Germany

Department of Public Health; University of Helsinki; Helsinki; Finland

Department of Translational Neuroscience; UMC Utrecht Brain Center; University Medical Center Utrecht Utrecht University; Utrecht; Utrecht; The Netherlands

Department of Women's and Children's Health; University of Padova; Padova; Italy

Discipline of Psychology; Curtin University; Perth; Western Australia; Australia

Discipline of Psychology; Flinders Institute for Mental Health and Wellbeing; Adelaide; South Australia; Australia

Division of Human Genetics; Children's Hospital of Philadelphia; Philadelphia; Pennsylvania; United States

Division of Mental Health and Addiction; NORMENT KG Jebsen Centre; Oslo University Hospital; Oslo; Norway

Division of Psychological and Social Medicine and Developmental Neuroscience; Technische Universitat Dresden; Dresden; Germany

Eating Disorder Research and Treatment Center Department of Child and Adolescent Psychiatry; Faculty of Medicine; Technische Universitat Dresden; Dresden; Germany

Eating Disorders Unit Department of Child and Adolescent Psychiatry; Medical University of Vienna; Vienna; Austria

Eating Disorders Unit; Parkland Klinik; Bad Wildungen; Germany

Eating Recovery Center; Denver; Colorado; United States

Eating Recovery Center; Hunt Valley; Maryland; United States

Estonian Genome Centre Institute of Genomics; University of Tartu; Tartu; Estonia

Faculty of Medicine; Sigmund Freud University; Vienna; Austria

German Center for Mental Health ; Berlin Potsdam; Germany

German Centre for Mental Health Tuebingen; University Tuebingen; Tuebingen; Germany

GGZ Rivierduinen Eating Disorders Ursula; Leiden; The Netherlands

Graduate Program in Bioinformatics; University of British Columbia; Vancouver; British Columbia; Canada

Great Ormond Street Institute of Child Health; University College London; London; United Kingdom

Groningen Institute for Evolutionary Life Sciences; University of Groningen; Groningen; The Netherlands

Helmholtz Zentrum Munchen German Research Centre for Environmental Health; Institute of Translational Genomics; Neuherberg; Germany

Human Genomics Research Group Department of Biomedicine; University of Basel; Basel; Basel Stadt; Switzerland

INSERM U1124; Universite de Paris; Paris; Ile de France; France

INSERM U1266; INSERM U1266; Paris; Ile de France; France

InsideOut Institute; University of Sydney; Sydney; Australia

Institute for Human Genetics; University of Bonn School of Medicine and University Hospital Bonn; Bonn; Northrhine Westfalia; Germany

Institute for Molecular Medicine Finland FIMM Helsinki Institute of Life Science HiLIFE; University of Helsinki; Helsinki; Finland

Institute of Applied Health Sciences; University of Aberdeen; Aberdeen; Scotland; United Kingdom

Institute of Biological Psychiatry; Mental Health Center Sct Hans; Mental Health Services Copenhagen; Roskilde; Denmark

Institute of Biology and Medical Genetics; 1st Faculty of Medicine; Charles University; Prague; Czech Republic

Institute of Clinical Medicine; University of Oslo; Oslo; Norway

Institute of Environmental Medicine; Karolinska Institutet; Stockholm; Sweden

Institute of Mathematics and Statistics; University of Tartu; Tartu; Estonia

Institute of Neuroscience and Medicine ; Research Center Juelich; Juelich; Germany

Institute of Psychiatric Phenomics and Genomics ; Ludwig Maximilians Universitat Munchen; Munich; Germany

Institute of Psychiatry Psychology and Neuroscience Social Genetic and Developmental Psychiatry Centre; King's College London; London; United Kingdom

Institute of Public Health and Clinical Nutrition; University of Eastern Finland; Kuopio; Finland

Institute of Sex and Gender Sensitive Medicine; University Hospital Essen University of Duisburg Essen; Essen; Northrhine Westfalia; Germany

KG Jebsen Centre for Neurodevelopmental Disorders Research; University of Oslo; Oslo; Norway

Maria Sklodowska Curie National research Institute of Oncology; Warsaw; Poland

McLaughlin Centre and Department of Molecular Genetics; University of Toronto; Toronto; Ontario; Canada

MRC Integrative Epidemiology Unit Population Health Sciences; Bristol Medical School; University of Bristol; Bristol; United Kingdom

National Center for PTSD; VA Boston Healthcare System; Boston; Massachusetts; United States

National Centre for Register based Research; Aarhus University; Aarhus; Denmark

National Institute for Health and Care Research Maudsley Biomedical Research Centre; South London and Maudsley NHS Foundation Trust; London; United Kingdom

National Institute for Health Research Biomedical Research Centre; King's College London and South London and Maudsley National Health Service Trust; London; United Kingdom

Oregon Research Institute; Springfield; Oregon; United States

Padova Neuroscience Center; University of Padova; Padova; Italy

PsychGen Centre for Genetic Epidemiology and Mental Health; Norwegian Institute of Public Health; Oslo; Norway

Psychiatric Genetic Epidemiology Group Research Department; Lovisenberg Diakonale Hospital; Oslo; Norway

Psychiatry and Behavioral Science; University of North Dakota; Fargo; North Dakota; United States

Psychoneurobiology of Eating and Addictive Behaviors Research Group; Bellvitge Biomedical Research Institute ; Barcelona; Catalonia; Spain

Research Department; Quantitative Genomics Laboratories ; Barcelona; Catalonia; Spain

Rheumatology Research Group; Vall d'Hebron Research Institute; Barcelona; Catalonia; Spain

Sainte Anne hospital ; GHU Paris Psychiatrie et Neurosciences; Paris; Ile de France; France

School of Psychology and Counselling; Queensland University of Technology; Brisbane; Queensland; Australia

School of Psychology; University of Queensland; Brisbane; Queensland; Australia

Section for Molecular Genetics in Mental Disorders; LVR University Clinic Essen University of Duisburg Essen; Essen; Northrhine Westfalia; Germany

Specialist Mental Health Clinical Research Unit; Health New Zealand Canterbury; Christchurch; New Zealand

Stanley Center for Psychiatric Research; Broad Institute of the Massachusetts Institute of Technology and Harvard University; Cambridge; Massachusetts; United States

Tanenbaum Centre; Centre for Addiction and Mental Health; Toronto; Ontario; Canada

The Centre for Applied Genomics Program in Genetics and Genomic Biology; The Hospital for Sick Children; Toronto; Ontario; Canada

The Lundbeck Foundation Initiative for Integrative Psychiatric Research ; Aarhus University; Aarhus; Denmark

The Weindrich Department of AI and Human Health; Icahn School of Medicine at Mount Sinai; New York; New York; United States

Universite Paris Cite INSERM U1266 ; Institute of Psychiatry and Neuroscience of Paris; Paris; Ile de France; France

Universite Paris Cite; Paris; Ile de France; France

Vanderbilt Genetics Institute; Vanderbilt University; Nashville; Tennessee; United States

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