Department of Internal Medicine University Hospital Královské Vinohrady and 3rd Faculty of Medicine Charles University Prague Czech Republic

I2MC INSERM Université de Toulouse Toulouse France

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Hansen M., Lange K. K., Stausholm M. B., and Dela F., “Are Individuals With Type 2 Diabetes Metabolically Inflexible? A Systematic Review and Meta‐Analysis,” Endocrinology, Diabetes & Metabolism 8 (2025): e70044, 10.1002/EDM2.70044. PubMed DOI PMC

Rubino F., Cummings D. E., Eckel R. H., et al., “Definition and Diagnostic Criteria of Clinical Obesity,” Lancet Diabetes & Endocrinology 13 (2025): 221–262, 10.1016/S2213-8587(24)00316-4. PubMed DOI PMC

Levelt E., Pavlides M., Banerjee R., et al., “Ectopic and Visceral Fat Deposition in Lean and Obese Patients With Type 2 Diabetes,” Journal of the American College of Cardiology 68 (2016): 53–63, 10.1016/J.JACC.2016.03.597. PubMed DOI PMC

Glaves A., Díaz‐Castro F., Farías J., Ramírez‐Romero R., Galgani J. E., and Fernández‐Verdejo R., “Association Between Adipose Tissue Characteristics and Metabolic Flexibility in Humans: A Systematic Review,” Frontiers in Nutrition 8 (2021): 744187, 10.3389/fnut.2021.744187. PubMed DOI PMC

Brouwers B., Schrauwen‐Hinderling V. B., Jelenik T., et al., “Metabolic Disturbances of Non‐Alcoholic Fatty Liver Resemble the Alterations Typical for Type 2 Diabetes,” Clinical Science (London, England) 131 (2017): 1905–1917, 10.1042/CS20170261. PubMed DOI

Chomentowski P., Coen P. M., Radiková Z., Goodpaster B. H., and Toledo F. G. S., “Skeletal Muscle Mitochondria in Insulin Resistance: Differences in Intermyofibrillar Versus Subsarcolemmal Subpopulations and Relationship to Metabolic Flexibility,” Journal of Clinical Endocrinology and Metabolism 96 (2011): 494–503, 10.1210/JC.2010-0822. PubMed DOI PMC

Jahn L. A., Hartline L., Liu Z., and Barrett E. J., “Metformin Improves Skeletal Muscle Microvascular Insulin Resistance in Metabolic Syndrome,” American Journal of Physiology. Endocrinology and Metabolism 322 (2022): E173–E180, 10.1152/AJPENDO.00287.202110.1152/AJPENDO.00287.2021/ASSET/IMAGES/LARGE/AJPENDO.00287.2021_F005.JPEG. PubMed DOI PMC

Veleba J., Kopecky J., Janovska P., et al., “Combined Intervention With Pioglitazone and n‐3 Fatty Acids in Metformin‐Treated Type 2 Diabetic Patients: Improvement of Lipid Metabolism,” Nutrition & Metabolism 12 (2015): 52, 10.1186/S12986-015-0047-9. PubMed DOI PMC

Hübinger A., Knode O., Susanto F., Reinauer H., and Cries F. A., “Effects of the Carnitine‐Acyltransferase Inhibitor Etomoxir on Insulin Sensitivity, Energy Expenditure and Substrate Oxidation in NIDDM,” Hormone and Metabolic Research = Hormon‐Und Stoffwechselforschung = Hormones et Métabolisme 29 (1997): 436–439, 10.1055/S-2007-979072. PubMed DOI

Christ‐Roberts C. Y., Pratipanawatr T., Pratipanawatr W., et al., “Exercise Training Increases Glycogen Synthase Activity and GLUT4 Expression but Not Insulin Signaling in Overweight Nondiabetic and Type 2 Diabetic Subjects,” Metabolism 53 (2004): 1233–1242, 10.1016/j.metabol.2004.03.022. PubMed DOI

Færch K. and Vaag A., “Metabolic Inflexibility Is a Common Feature of Impaired Fasting Glycaemia and Impaired Glucose Tolerance,” Acta Diabetologica 48 (2011): 349–353, 10.1007/S00592-010-0245-X. PubMed DOI

McDougal D. H., Marlatt K. L., Beyl R. A., Redman L. M., and Ravussin E., “A Novel Approach to Assess Metabolic Flexibility Overnight in a Whole‐Body Room Calorimeter,” Obesity 28 (2020): 2073–2077, 10.1002/OBY.22982. PubMed DOI PMC

Carnero E. A., Bock C. P., Distefano G., et al., “Twenty‐Four Hour Assessments of Substrate Oxidation Reveal Differences in Metabolic Flexibility in Type 2 Diabetes That Are Improved With Aerobic Training,” Diabetologia 64 (2021): 2322–2333, 10.1007/S00125-021-05535-Y. PubMed DOI

Goodpaster B. H. and Sparks L. M., “Metabolic Flexibility in Health and Disease,” Cell Metabolism 25 (2017): 1027–1036, 10.1016/J.CMET.2017.04.015. PubMed DOI PMC

Galgani J. E. and Fernández‐Verdejo R., “Pathophysiological Role of Metabolic Flexibility on Metabolic Health,” Obesity Reviews 22 (2021): e13131, 10.1111/obr.13131. PubMed DOI

Galgani J. E., Moro C., and Ravussin E., “Metabolic Flexibility and Insulin Resistance,” American Journal of Physiology. Endocrinology and Metabolism 295 (2008): E1009–E1017, 10.1152/AJPENDO.90558.2008. PubMed DOI PMC

Smith R. L., Soeters M. R., Wüst R. C. I., and Houtkooper R. H., “Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease,” Endocrine Reviews 39 (2018): 489–517, 10.1210/ER.2017-00211. PubMed DOI PMC