Integrator complex collapse: A mechanistic route to integrated stress response and disease
Language English Country United States Media print
Document type Journal Article
PubMed
40541166
DOI
10.1016/j.molcel.2025.05.024
PII: S1097-2765(25)00463-0
Knihovny.cz E-resources
- MeSH
- RNA, Double-Stranded metabolism genetics MeSH
- Stress, Physiological * MeSH
- Humans MeSH
- Neurodevelopmental Disorders * genetics metabolism MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- RNA, Double-Stranded MeSH
In a recent Cell article, Baluapuri et al.1 show that loss of the Integrator (INT) complex activates the integrated stress response via double-stranded RNA from incomplete pre-mRNAs, revealing a link to INT-related neurodevelopmental diseases and potential therapeutic targets.
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