A Bambusuril Receptor Binds Charge Diffuse Anions in Water at Picomolar Concentrations
Status PubMed-not-MEDLINE Language English Country Germany Media print-electronic
Document type Journal Article
Grant support
23-05271S
the Czech Science Foundation
CZ.02.01.01/00/22_010/0008854
OP JAC - Project MSCAfellow7_MUNI
LM2023069
RECETOX Research Infrastructure
857560
the European Union's Horizon 2020 Research and Innovation Programme
CZ.02.01.01/00/23_015/0008175
Czech Infrastructure for Integrative Structural Biology
LM2023052
the National Infrastructure for Chemical Biology
PubMed
40728136
PubMed Central
PMC12416460
DOI
10.1002/anie.202510912
Knihovny.cz E-resources
- Keywords
- Bambusurils, Binding in water, Chaotropic effect, Macrocycles, Supramolecular chemistry,
- Publication type
- Journal Article MeSH
Anionic pollutants are widespread in the environment and pose risks to human health. Due to the typically low concentrations of these species, the development of efficient receptors for their detection and removal from aqueous solutions is highly desirable. Here, we report the design and synthesis of a bambusuril receptor with markedly enhanced anion-binding affinity in water, achieved by introducing trifluoromethyl electron-withdrawing groups. The resulting fluorinated receptor is, to date, the most potent known receptor for several charge diffuse anions in aqueous media. The most stable 1:1 host-guest complex in water was observed with iodide, exhibiting a relative dissociation constant of 59 pM. This complex is over three orders of magnitude more stable than any previously reported complex between an artificial receptor and inorganic anion in water.
Department of Chemistry Faculty of Science Masaryk University Kamenice 5 625 00 Brno Czech Republic
RECETOX Faculty of Science Masaryk University Kamenice 5 625 00 Brno Czech Republic
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