An 8-year-old female with Albright's hereditary osteodystrophy (AHO) presented with severe right buttock pain, difficulty walking, and a palpable mass in the right ischiofemoral region. Imaging studies demonstrated a large, ossified lesion compressing the sciatic nerve. Surgical resection of the mass resulted in complete resolution of symptoms and restoration of normal gait and function. AHO is a rare genetic disorder caused by mutations in the GNAS1 gene and is characterized by musculoskeletal abnormalities, including a predisposition to subcutaneous ossifications. While osteochondromas are typically asymptomatic, they can cause significant clinical symptoms when they enlarge or impinge on adjacent neurovascular structures. This case illustrates the rare co-occurrence of AHO and a symptomatic giant osteochondroma, underscoring the importance of early recognition and surgical intervention to prevent functional impairment due to neurovascular compression.

Department of Orthopedics 1st Medical Faculty Charles University University Hospital Na Bulovce Prague Czech Republic

Meharry Medical College Nashville TN USA

Orthopaedic Surgery Department University of Missouri Columbia MO USA

The University of South Carolina School of Medicine Columbia SC USA

Unidad de Patología Oncológica Musculo Esquelética Instituto Nacional de Ortopedia y Traumatología Montevideo Uruguay

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