Department of Internal Medicine Hematology and Oncology University Hospital Brno and Masaryk University Brno Czech Republic

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Tan YY, Papez V, Chang WH, Mueller SH, Denaxas S, Lai AG (2022) Comparing clinical trial population representativeness to real-world populations: an external validity analysis encompassing 43 895 trials and 5 685 738 individuals across 989 unique drugs and 286 conditions in England. Lancet Healthy Longev 3(10):e674–e689. 10.1016/S2666-7568(22)00186-6 PubMed DOI

Blonde L, Khunti K, Harris SB, Meizinger C, Skolnik NS (2018) Interpretation and impact of real-world clinical data for the practicing clinician. Adv Ther 35(11):1763–1774. 10.1007/s12325-018-0805-y PubMed DOI PMC

Elting LS, Cooksley C, Bekele BN, Frumovitz M, Avritscher EB, Sun C, Bodurka DC (2006) Generalizability of cancer clinical trial results: prognostic differences between participants and nonparticipants. Cancer 106(11):2452–2458. 10.1002/cncr.21907 PubMed DOI

Peppercorn JM, Weeks JC, Cook EF, Joffe S (2004) Comparison of outcomes in cancer patients treated within and outside clinical trials: conceptual framework and structured review. Lancet 363(9405):263–270. 10.1016/S0140-6736(03)15383-4 PubMed DOI

Unger JM, Barlow WE, Martin DP, Ramsey SD, Leblanc M, Etzioni R et al (2014) Comparison of survival outcomes among cancer patients treated in and out of clinical trials. J Natl Cancer Inst 106(3):dju002. 10.1093/jnci/dju002 PubMed DOI PMC

Tiong IS, Wall M, Bajel A, Kalro A, Fleming S, Roberts AW, Australasian Leukaemia and Lymphoma Group (ALLG) et al (2024) How comparable are patient outcomes in the “real-world” with populations studied in pivotal AML trials? Blood Cancer J 14(1):54. 10.1038/s41408-024-00996-x PubMed DOI PMC

Bruno DS, Khanal M, Li X, Escalon MP, Winfree K, Hess LM (2025) Clinical trial participation, clinical care, and patient outcomes by practice setting: a real-world database analysis of patients with chronic lymphocytic leukemia or mantle cell lymphoma. Hematology 30(1):2457809. 10.1080/16078454.2025.2457809 PubMed DOI

Bertamini L, Bertuglia G, Oliva S (2022) Beyond clinical trials in patients with multiple myeloma: a critical review of real-world results. Front Oncol 12:844779. 10.3389/fonc.2022.844779 PubMed DOI PMC

Hoffmann VS, Baccarani M, Hasford J, Lindoerfer D, Burgstaller S, Sertic D et al (2015) The EUTOS population-based registry: incidence and clinical characteristics of 2904 CML patients in 20 European countries. Leukemia 29(6):1336–1343. 10.1038/leu.2015.73 PubMed DOI

Hoffmann VS, Baccarani M, Hasford J, Castagnetti F, Di Raimondo F, Casado LF et al (2017) Treatment and outcome of 2904 CML patients from the EUTOS population-based registry. Leukemia 31(3):593–601. 10.1038/leu.2016.246 PubMed DOI

Makady A, de Boer A, Hillege H, Klungel O, Goettsch W (2017) What is real-world data? A review of definitions based on literature and stakeholder interviews. Value Health 20(7):858–865. 10.1016/j.jval.2017.03.008 PubMed DOI

Derman BA, Belli AJ, Battiwalla M, Hamadani M, Kansagra A, Lazarus HM et al (2022) Reality check: Real-world evidence to support therapeutic development in hematologic malignancies. Blood Rev 53:100913. 10.1016/j.blre.2021.100913 PubMed DOI

Wood WA, Marks P, Plovnick RM, Hewitt K, Neuberg DS, Walters S, Dolan Brendan K., Tucker Emily A., Abrams Charles S., Thompson Alexis A., Anderson Kenneth C., Kluetz Paul, Farrell Ann, Rivera Donna, Gertzog Matthew, Pappas Gregory (2021) ASH research collaborative: a real-world data infrastructure to support real-world evidence development and learning healthcare systems in hematology. Blood Adv 5(23):5429–5438. 10.1182/bloodadvances.2021005902 PubMed DOI PMC