Structural brain abnormalities and aggression in schizophrenia: mega-analysis of data from 2095 patients and 2861 healthy controls via the ENIGMA consortium
Status Publisher Jazyk angličtina Země Velká Británie, Anglie Médium print-electronic
Typ dokumentu časopisecké články
PubMed
41339704
DOI
10.1038/s41380-025-03365-7
PII: 10.1038/s41380-025-03365-7
Knihovny.cz E-zdroje
- Publikační typ
- časopisecké články MeSH
It is hypothesised that structural brain abnormalities in individuals with schizophrenia are associated with aggressive behaviour, but this has not been tested directly. We pooled magnetic resonance imaging and clinical data from 2095 patients and 2861 healthy control subjects across 20 sites of the ENIGMA-Schizophrenia Working Group. Using normative modelling, we quantified individual-level deviations from controls (z-scores) for global and regional grey matter volume and white matter microstructural integrity. Ordinal regression models were used to estimate the associations between these deviations and concurrent aggression (odds ratios [ORs] with 99% confidence intervals [CIs]). In mediation analyses, we examined the roles of positive symptoms - delusions, hallucinations and disorganised thinking - impulsivity and illness insight. Aggression was significantly associated with reductions in total cortical volume (OR [99% CI] = 0.88 [0.78, 0.98], p = 0.003), global white matter integrity (OR [99% CI] = 0.72 [0.59, 0.88], p = 3.50 × 10-5), dorsolateral prefrontal cortex volume (OR [99% CI] = 0.85 [0.74, 0.97], p = 0.002), inferior parietal lobule volume (OR [99% CI] = 0.76 [0.66, 0.87], p = 2.20 × 10-7) and internal capsule integrity (OR [99% CI] = 0.76 [0.63, 0.92], p = 2.90 × 10-4). These associations were robust to adjustment for relevant covariates and partly mediated by positive symptoms and impulsivity. Our findings suggest that the co-occurrence of positive symptoms, impulsivity and aggression in schizophrenia has a neurobiological basis, providing potential targets for therapeutic interventions.
Center for the Neurobiology of Learning and Memory University of California Irvine Irvine CA USA
Centre de Recherche de l'Institut Universitaire en Santé Mentale de Montréal Montreal Canada
Centro de Investigación Biomédica en Red de Salud Mental Carlos 3 Health Institute Madrid Spain
Department of Advanced Biomedical Sciences University of Naples Federico 2 Naples Italy
Department of Child and Adolescent Psychiatry and Psychotherapy TU Dresden Dresden Germany
Department of Complex Trait Genetics Vrije Universiteit Amsterdam Amsterdam the Netherlands
Department of Criminology University of Pennsylvania Philadelphia PA USA
Department of Criminology Vrije Universiteit Amsterdam Amsterdam the Netherlands
Department of Neuropsychiatry Seoul National University Hospital Seoul South Korea
Department of Psychiatry and Addictology University of Montreal Montreal Canada
Department of Psychiatry and Behavioral Science UTHealth Houston Houston TX USA
Department of Psychiatry and Behavioral Sciences Northwestern University Chicago IL USA
Department of Psychiatry and Human Behavior University of California Irvine Irvine USA
Department of Psychiatry and Psychotherapy Otto von Guericke University Magdeburg Germany
Department of Psychiatry and Psychotherapy Philipps University Marburg Marburg Germany
Department of Psychiatry and Psychotherapy University of Lübeck University of Lübeck Lübeck Germany
Department of Psychiatry Harvard Medical School Harvard MA USA
Department of Psychiatry Jeonbuk National University Hospital Jeonju South Korea
Department of Psychiatry Jeonbuk National University Jeonju South Korea
Department of Psychiatry Psychotherapy and Psychosomatics University of Zürich Zürich Switzerland
Department of Psychiatry Seoul National University College of Medicine Seoul South Korea
Department of Psychiatry University Hospitals of Geneva Geneva Switzerland
Department of Psychiatry University Medical Center Utrecht Utrecht the Netherlands
Department of Psychiatry University of Iowa Iowa City IA USA
Department of Psychiatry University of Pennsylvania Philadelphia PA USA
Department of Psychology and Neuroscience Center Brigham Young University Provo UT USA
Department of Psychology Georgia State University Atlanta GA USA
Department of Psychology University of Pennsylvania Philadelphia PA USA
Department of Psychology Utrecht University Utrecht the Netherlands
Department of Research Institute of Mental Health Singapore Singapore
Department of Youth Psychiatry Mental Health Research Center Moscow Russia
Donders Institute for Brain Cognition and Behaviour Radboud University Nijmegen the Netherlands
Faculty of Electrical Engineering Czech Technical University Prague Prague Czech Republic
FIDMAG Germanes Hospitalaries Research Foundation Barcelona Spain
Hospital Benito Menni CASM Barcelona Spain
Institut Philippe Pinel Montreal Canada
Institute for Translational Neuroscience University of Münster Münster Germany
Institute for Translational Psychiatry University of Münster Münster Germany
Institute of Behavioral Science Feinstein Institutes for Medical Research Manhasset NY USA
Institute of Clinical Sciences Imperial College London London UK
Institute of Computer Science Czech Academy of Sciences Prague Czech Republic
Institute of Psychiatry Psychology and Neuroscience King's College London London UK
Iowa Neuroscience Institute University of Iowa Iowa City IA USA
Laboratory of Neuroimaging and Multimodal Analysis Mental Health Research Center Moscow Russia
Laboratory of Neuropsychiatry Santa Lucia Foundation IRCCS Rome Italy
Montreal Neurological Institute Hospital McGill University Montreal Canada
MRC London Institute of Medical Sciences Imperial College London London UK
National Institute of Mental Health Klecany Czech Republic
Neuroscience Research Australia Randwick Australia
Olin Neuropsychiatry Research Center Institute of Living Hartford IN USA
Psychiatry and Behavioral Health Ohio State University Wexner Medical Center Columbus USA
School of Clinical Medicine University of New South Wales Sydney Australia
School of Psychology University of New South Wales Sydney Australia
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