Calcimycin [calcimycin]

topical
21
Terms

A23187
kalcimycin

 

4-Benzoxazolecarboxylic acid, 5-(methylamino)-2-((3,9,11-trimethyl-8-(1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl)-1,7-dioxaspiro(5.5)undec-2-yl)methyl)-, (6S-(6alpha(2S*,3S*),8beta(R*),9beta,11alpha))-
A-23187
A23187
Antibiotic A23187

Persistent link   https://www.medvik.cz/link/D000001
Definition

An ionophorous, polyether antibiotic from Streptomyces chartreusensis. It binds and transports CALCIUM and other divalent cations across membranes and uncouples oxidative phosphorylation while inhibiting ATPase of rat liver mitochondria. The substance is used mostly as a biochemical tool to study the role of divalent cations in various biological systems.

DUI
D000001 MeSH Browser
CUI
M0000001
Previous indexing
Antibiotics (1973-1974); Carboxylic Acids (1973-1974)
History note
91(75); was A 23187 1975-90 (see under ANTIBIOTICS 1975-83)
Online note
use CALCIMYCIN to search A 23187 1975-90
Public note
91; was A 23187 1975-90 (see under ANTIBIOTICS 1975-83)

Allowable subheadings

AD
administration & dosage 1
AE
adverse effects 0
AG
agonists 0
AA
analogs & derivatives 0
AN
analysis 0
AI
antagonists & inhibitors 2
BI
biosynthesis 0
BL
blood 0
CF
cerebrospinal fluid 0
CS
chemical synthesis 0
CH
chemistry 0
CL
classification 0
EC
economics 0
HI
history 0
IM
immunology 0
IP
isolation & purification 0
ME
metabolism 0
PK
pharmacokinetics 0
PD
pharmacology 17
PO
poisoning 0
RE
radiation effects 0
ST
standards 0
SD
supply & distribution 0
TU
therapeutic use 0
TO
toxicity 2
UR
urine 0

D Chemicals and Drugs
D02 Organic Chemicals 391
D02.355 Ethers 45
D02.355.291 Ethers, Cyclic 9
D02.355.291.933 Polyether Polyketides
D02.355.291.933.063 Amphidinols
D02.355.291.933.125 Calcimycin 21
D02.355.291.933.250 Lasalocid 1
D02.355.291.933.500 Monensin 21
D02.355.291.933.750 Nigericin 2
D02.355.291.933.875 Polyether Toxins
D02.540 Lactones 204
D02.540.576 Polyketides 12
D02.540.576.625 Polyether Polyketides
D02.540.576.625.063 Amphidinols
D02.540.576.625.125 Calcimycin 21
D02.540.576.625.188 Ciguatoxins 3
D02.540.576.625.250 Lasalocid 1
D02.540.576.625.500 Monensin 21
D02.540.576.625.750 Nigericin 2
D02.540.576.625.937 Polyether Toxins
D03 Heterocyclic Compounds 189
D03.633 Heterocyclic Compounds, Fused-Ring
D03.633.100 Heterocyclic Compounds, 2-Ring 24
D03.633.100.221 Benzoxazoles 32
D03.633.100.221.173 Calcimycin 21
D03.633.100.221.346 Chlorzoxazone 2
D03.633.100.221.370 Cialit 1
D03.633.100.221.950 Zoxazolamine 1
D04 Polycyclic Compounds 65
D04.345 Macrocyclic Compounds 20
D04.345.241 Ethers, Cyclic 9
D04.345.241.654 Polyether Polyketides
D04.345.241.654.063 Amphidinols
D04.345.241.654.125 Calcimycin 21
D04.345.241.654.188 Ciguatoxins 3
D04.345.241.654.250 Lasalocid 1
D04.345.241.654.500 Monensin 21
D04.345.241.654.750 Nigericin 2
D04.345.241.654.937 Polyether Toxins
D04.345.674 Polyketides 12
D04.345.674.625 Polyether Polyketides
D04.345.674.625.063 Amphidinols
D04.345.674.625.125 Calcimycin 21
D04.345.674.625.188 Ciguatoxins 3
D04.345.674.625.250 Lasalocid 1
D04.345.674.625.500 Monensin 21
D04.345.674.625.750 Nigericin 2
D04.345.674.625.937 Polyether Toxins

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