Enhancer of Zeste Homolog 2 Protein [EZH2 protein]
- Terms
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histon-methyltransferáza EZH2
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Enhancer of Zeste Homolog 2
Histone-Lysine N-Methyltransferase EZH2
Lysine N-Methyltransferase-6
A histone-lysine N-methyltransferase and catalytic subunit of Polycomb Repressive Complex 2. It methylates LYSINE 9 (H3K9me) and LYSINE 27 (H3K27me) of HISTONE H3, leading to transcriptional repression of the affected target gene. EZH2 also methylates non-histone proteins such as GATA4 TRANSCRIPTION FACTOR and the nuclear receptor RORA. It regulates CIRCADIAN CLOCKS via histone methylation of circadian protein gene PROMOTER REGIONS, and its repressive activity is also important for the identity and differentiation of EMBRYONIC STEM CELLS.
- DUI
- D000071221 MeSH Browser
- CUI
- M000613664
- History note
- 2017 (2005)
- Public note
- 2017; ENHANCER OF ZESTE HOMOLOG 2 was indexed under POLYCOMB REPRESSIVE COMPLEX 2 2013-2016, under DNA-BINDING PROTEINS and TRANSCRIPTION FACTORS 2005-2012, and under PROTEINS 2005
Allowable subheadings
- AD
- administration & dosage
- AE
- adverse effects
- AN
- analysis
- AI
- antagonists & inhibitors
- BI
- biosynthesis 1
- BL
- blood
- CF
- cerebrospinal fluid
- CS
- chemical synthesis
- CH
- chemistry
- CL
- classification
- DF
- deficiency
- DE
- drug effects
- EC
- economics
- GE
- genetics 4
- HI
- history
- IM
- immunology
- IP
- isolation & purification
- ME
- metabolism 2
- PK
- pharmacokinetics
- PD
- pharmacology 1
- PH
- physiology
- PO
- poisoning
- RE
- radiation effects
- ST
- standards
- SD
- supply & distribution
- TU
- therapeutic use
- TO
- toxicity
- UL
- ultrastructure
- UR
- urine
EZH2 protein, Xenopus Chemical MeSH Browser
EZH2 protein, human Chemical MeSH Browser
EZH2 protein, rat Chemical MeSH Browser
ezh2 protein, zebrafish Chemical MeSH Browser