A suppressor of cytokine signaling protein that consists of an N-terminal kinase-inhibitory region, a central SH2 DOMAIN, a characteristic C-terminal SOCS box (a 40-amino acid motif, which functions to recruit E3 UBIQUITIN-PROTEIN LIGASE COMPLEXES). SOCS1 functions as a negative regulator of CYTOKINES that signal through the JANUS KINASES-STAT 3 TRANSCRIPTION FACTOR (JAK/STAT3) pathway by inhibiting the activity of JANUS KINASES.

DUI

D000071222 MeSH Prohlížeč

CUI

M000613665

Předchozí užití

Carrier Proteins (1997-2016); Intracellular Signaling Peptides and Proteins (2004-2016); Repressor Proteins (2004-2016); Suppressor of Cytokine Signaling Proteins (2006-2016)

Historická pozn.

2017

Veřejná pozn.

2017