Suppressor of Cytokine Signaling 1 Protein [protein SOCS1]
- Terms
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SOCS1 protein
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SOCS1 Protein
Suppressor of Cytokine Signaling Protein 1 -
A suppressor of cytokine signaling protein that consists of an N-terminal kinase-inhibitory region, a central SH2 DOMAIN, a characteristic C-terminal SOCS box (a 40-amino acid motif, which functions to recruit E3 UBIQUITIN-PROTEIN LIGASE COMPLEXES). SOCS1 functions as a negative regulator of CYTOKINES that signal through the JANUS KINASES-STAT 3 TRANSCRIPTION FACTOR (JAK/STAT3) pathway by inhibiting the activity of JANUS KINASES.
- DUI
- D000071222 MeSH Browser
- CUI
- M000613665
- Previous indexing
- Carrier Proteins (1997-2016); Suppressor of Cytokine Signaling Proteins (2006-2016); Intracellular Signaling Peptides and Proteins (2004-2016); Repressor Proteins (2004-2016)
- History note
- 2017
- Public note
- 2017
Allowable subheadings
- AD
- administration & dosage
- AE
- adverse effects
- AG
- agonists
- AN
- analysis
- AI
- antagonists & inhibitors
- BI
- biosynthesis
- BL
- blood
- CF
- cerebrospinal fluid
- CS
- chemical synthesis
- CH
- chemistry
- CL
- classification
- DF
- deficiency
- DE
- drug effects
- EC
- economics
- GE
- genetics
- HI
- history
- IM
- immunology
- IP
- isolation & purification
- ME
- metabolism
- PK
- pharmacokinetics
- PD
- pharmacology
- PH
- physiology
- PO
- poisoning
- RE
- radiation effects
- ST
- standards
- SD
- supply & distribution
- TU
- therapeutic use
- TO
- toxicity
- UL
- ultrastructure
- UR
- urine
SOCS1 protein, human Chemical MeSH Browser
Socs1 protein, mouse Chemical MeSH Browser
Socs1 protein, rat Chemical MeSH Browser
socs1a protein, zebrafish Chemical MeSH Browser