A mammalian enzyme composed of a heterodimer of alpha and beta subunits. Each subunit consists of four domains; N-terminal HNOX domain, PAS-like domain, a coiled-coil domain, and a C-terminal catalytic domain. All four domains are homologous proteins with a similar conformation of functional domains. Soluble guanylate cyclase catalyzes the formation of cyclic GMP from GTP, and is a key enzyme of the nitric oxide signaling pathway involved in the regulation of a variety of biological and physiological processes in mammals.

DUI

D000071756 MeSH Browser

CUI

M0400048

History note

2017 (2016)

Public note

2017; SOLUBLE GUANYLYL CYCLASE was indexed under GUANYLATE CYCLASE and RECEPTORS, CYTOPLASMIC AND NUCLEAR 2001-2016