Bestrophins [bestrofiny]

topical
1
Terms

BEST1
protein bestrofin-1
protein bestrofin-2

 

BEST-1 Protein
BEST-2 Protein
Bestrophin
Bestrophin Family
Bestrophin Proteins
Bestrophin-1
Bestrophin-2

Definition

A protein family characterized by a highly conserved N-terminus and four to six transmembrane helices; they function as bicarbonate permeable, calcium-activated chloride channels. Bestrophin-1 (BEST-1) and bestrophin-2 are highly expressed in human RETINAL PIGMENT EPITHELIUM cells and mutations in the BEST-1 gene are associated with VITELLIFORM MACULAR DYSTROPHY, TYPE 2.

DUI
D000075002 MeSH Browser
CUI
M000628883
Previous indexing
Chloride Channels (1999-2017); Eye Proteins (1999-2017)
History note
2018
Public note
2018

D Chemicals and Drugs
D12.776 Proteins 2 581
D12.776.157 Carrier Proteins 546
D12.776.157.530 Membrane Transport Proteins 207
D12.776.157.530.400 Ion Channels 276
D12.776.157.530.400.175 Chloride Channels 36
D12.776.157.530.400.175.032 Anoctamins
D12.776.157.530.400.175.063 Bestrophins 1
D12.776.157.530.400.175.094 CLC-2 Chloride Channels
D12.776.157.530.400.175.562 Receptors, GABA-A 70
D12.776.157.530.400.175.781 Receptors, Glycine 9
D12.776.306 Eye Proteins 53
D12.776.306.090 Arrestins 6
D12.776.306.228 Bestrophins 1
D12.776.306.366 Crystallins 16
D12.776.306.450 Homeobox Protein SIX3
D12.776.306.466 Opsins 12
D12.776.306.750 Recoverin 1
D12.776.543 Membrane Proteins 850
D12.776.543.550 Membrane Glycoproteins 201
D12.776.543.550.450 Ion Channels 276
D12.776.543.550.450.175 Chloride Channels 36
D12.776.543.550.450.175.032 Anoctamins
D12.776.543.550.450.175.063 Bestrophins 1
D12.776.543.550.450.175.094 CLC-2 Chloride Channels
D12.776.543.550.450.175.562 Receptors, GABA-A 70
D12.776.543.550.450.175.781 Receptors, Glycine 9
D12.776.543.585 Membrane Transport Proteins 207
D12.776.543.585.400 Ion Channels 276
D12.776.543.585.400.175 Chloride Channels 36
D12.776.543.585.400.175.032 Anoctamins
D12.776.543.585.400.175.063 Bestrophins 1
D12.776.543.585.400.175.094 CLC-2 Chloride Channels
D12.776.543.585.400.175.562 Receptors, GABA-A 70
D12.776.543.585.400.175.781 Receptors, Glycine 9

BEST1 protein, human Chemical MeSH Browser

BEST2 protein, human Chemical MeSH Browser

BEST3 protein, human Chemical MeSH Browser

BEST4 protein, human Chemical MeSH Browser

Best1 protein, mouse Chemical MeSH Browser

Best1 protein, rat Chemical MeSH Browser

Best2 protein, mouse Chemical MeSH Browser

Best2 protein, rat Chemical MeSH Browser

Best3 protein, rat Chemical MeSH Browser

best1 protein, Drosophila Chemical MeSH Browser

best2 protein, Drosophila Chemical MeSH Browser

best3 protein, Drosophila Chemical MeSH Browser