Pregnane X Receptor [pregnanový X receptor]
- Terms
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NR1I2
pregnanový receptor X
PXR
steroid X receptor
SXR
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NR1I2
Nuclear Receptor Subfamily 1, Group I, Member 2
Steroid and Xenobiotic Receptor
Steroid X Receptor
SXR Receptor
Steroid receptor that binds and is activated by variety of endogenous compounds and XENOBIOTICS. It binds the response element in promoters of genes that encode CYTOCHROME P450 3A4 and ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1 proteins, and also activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs, and endogenous compounds. It is activated by the antibiotic RIFAMPICIN and various plant metabolites, such as hyperforin, guggulipid, colupulone, and ISOFLAVONES.
- DUI
- D000077297 MeSH Browser
- CUI
- M0287170
- History note
- 2019 (1998)
- Public note
- 2019; PREGNANE X RECEPTOR was indexed under RECEPTORS, STEROID 2007-2018; and under RECEPTORS, CYTOPLASMIC AND NUCLEAR 1998-2006
Allowable subheadings
- AD
- administration & dosage
- AG
- agonists 4
- AN
- analysis
- AI
- antagonists & inhibitors 1
- BI
- biosynthesis
- BL
- blood
- CH
- chemistry 2
- CL
- classification
- DF
- deficiency
- DE
- drug effects 1
- GE
- genetics 10
- HI
- history
- IM
- immunology
- IP
- isolation & purification
- ME
- metabolism 14
- PH
- physiology
- RE
- radiation effects
- TU
- therapeutic use
- UL
- ultrastructure
NR1I2 protein, human Chemical MeSH Browser
Nr1i2 protein, mouse Chemical MeSH Browser
Nr1i2 protein, rat Chemical MeSH Browser