Necroptosis [nekroptóza]

topical
15
Persistent link   https://www.medvik.cz/link/D000079302
Definition

A form of regulated cell death initiated by perturbations of extracellular or intracellular homeostasis that trigger a specific cell death pathway involving the activation of RIPK3 and MLKL (mixed lineage kinase domain like pseudokinase). Morphological changes include cytoplasmic and organellar swelling, rupture of the PLASMA MEMBRANE, and CHROMATIN CONDENSATION.

Annotation
do not confuse with NECROSIS the pathological process
DUI
D000079302 MeSH Browser
CUI
M000644214
Previous indexing
Necrosis (2005-2019)
History note
2020
Public note
2020

Allowable subheadings

DE
drug effects 3
GE
genetics 1
IM
immunology 0
PH
physiology 3
RE
radiation effects 0

G Phenomena and Processes
G01 Physical Phenomena 75
G02 Chemical Phenomena 307
G03 Metabolic Phenomena obsolete
G04 Cell Physiological Phenomena 514
G04.146 Cell Death 374
G04.146.954 Regulated Cell Death 5
G04.146.954.035 Apoptosis 2 050
G04.146.954.053 Autophagic Cell Death
G04.146.954.178 Ferroptosis 12
G04.146.954.285 Immunogenic Cell Death 8
G04.146.954.393 Mitochondrial Transmembrane Permeability-Driven Necrosis
G04.146.954.500 Necroptosis 15
G04.146.954.625 Paraptosis
G04.146.954.750 Parthanatos
G05 Genetic Phenomena 133
G06 Microbiological Phenomena 95
G07 Physiological Phenomena 175
G08 Reproductive and Urinary Physiological Phenomena 18
G09 Circulatory and Respiratory Physiological Phenomena 94
G10 Digestive System and Oral Physiological Phenomena 4
G11 Musculoskeletal and Neural Physiological Phenomena 16
G12 Immune System Phenomena 248
G13 Integumentary System Physiological Phenomena 14
G14 Ocular Physiological Phenomena 147
G15 Plant Physiological Phenomena 158
G16 Biological Phenomena 129
G17 Mathematical Concepts 66

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