Proteolysis Targeting Chimera [chiméra pro cílenou proteolýzu]
topical
- Terms
-
PROTAC
-
Cereblon-Based Small-Molecule Compounds
IAP-Based PROTACs
MDM2 Protein-Based PROTACs
Phospho-Dependent PROTACs
PhosphoPROTACs
PROTAC Proteolysis Targeting Chimera
PROTACs
Proteolysis Targeting Chimeras
VHL-Based PROTACs
Persistent link
https://www.medvik.cz/link/D000094243
Definition
Bifunctional molecules that are designed to recruit E3 UBIQUITIN LIGASE to a specific target protein. Proteolysis targeting chimera consist of a target protein ligand connected via a linker to an E3 ligand. They promote association of E3 with specific target proteins tagged for degradation via the PROTEASOME.
- DUI
- D000094243 MeSH Browser
- CUI
- M000755726
- Previous indexing
- Proteolysis (2015-2022)
- History note
- 2023
- Public note
- 2023
Allowable subheadings
- AD
- administration & dosage
- AE
- adverse effects
- AN
- analysis
- CS
- chemical synthesis
- CH
- chemistry
- CL
- classification
- EC
- economics
- HI
- history
- IP
- isolation & purification
- ME
- metabolism
- PK
- pharmacokinetics
- PD
- pharmacology
- PO
- poisoning
- RE
- radiation effects
- ST
- standards
- SD
- supply & distribution
- TU
- therapeutic use
- TO
- toxicity
...
Occurrences in Medvik records