ProTides [ProTide technologie]

topical
1
Terms

Pro-Tide
Pro-Tide přípravky
prodrug nukleotid
prodrug nukleotidy
proléčiva analogů nukleotidů
ProTide
ProTide proléčiva

 

Pro-Tide
Pro-Tides
Prodrug Nucleotide
Prodrug Nucleotides
ProTide

Definition

A class of prodrugs consisting of a 5'-nucleoside monophosphate in which the two hydroxyl groups are masked with an amino acid ester and an aryloxy component which once in the cell is enzymatically metabolized to deliver free 5'-monophosphate, and further transformed to the active 5'-triphosphate form of the nucleoside analogue.

DUI
D000095802 MeSH Browser
CUI
M000758863
History note
2024
Public note
2024

D Chemicals and Drugs
D13.695 Nucleotides 356
D13.695.065 Arabinonucleotides 3
D13.695.201 Deoxyribonucleotides 16
D13.695.225 Dideoxynucleotides 3
D13.695.462 Nucleotides, Cyclic 77
D13.695.578 Polynucleotides 46
D13.695.623 ProTides 1
D13.695.667 Purine Nucleotides 21
D13.695.827 Ribonucleotides 18
D13.695.900 Thionucleotides 8
D26.675 Prodrugs 221
D26.675.500 ProTides 1