Nudix Hydrolases [NUDIX hydrolasy]

topical
Terms

Nudix hydroláza
Nudix hydrolázy
NUDIX hydrolázy

 

Nucleoside Diphosphates-Linked to Moiety-X Hydrolases
Nudix Hydrolase
Nudix Proteins

Persistent link   https://www.medvik.cz/link/D000096964
Definition

A group of Mg2+/Mn2+-dependent mainly pyrophosphohydrolases that hydrolyzes structures of NUcleoside DIphosphate linked to another moiety X to nucleoside monophosphate and X-Phosphate. Nudix hydrolases share conserved Nudix box (GX5EX7REUXEEXGU) and degrade variety of substrates including oxidized nucleotides (e.g., MutT) and metabolic intermediates (e.g., THIAMINE PYROPHOSPHATASE). In humans, Nudix superfamily proteins such as MutT proteins participate in DNA damage repairs. Mutations on a nudix hydrolase (NUDT15) are associated with a PURINE-PYRIMIDINE METABOLISM, INBORN ERRORS disorder called THPM2, and mutations in nudix hydrolase (NUDT2) are associated with IDDPN, a developmental intellectual disorder.

DUI
D000096964 MeSH Browser
CUI
M000762793
History note
2024
Public note
2024; see under PYROPHOSPHATASES 1998-2023

Allowable subheadings

AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine

D Chemicals and Drugs
D01 Inorganic Chemicals 68
D02 Organic Chemicals 391
D03 Heterocyclic Compounds 192
D04 Polycyclic Compounds 66
D05 Macromolecular Substances 103
D06 Hormones, Hormone Substitutes, and Hormone Antagonists 43
D08 Enzymes and Coenzymes 7
D08.811 Enzymes 1 554
D08.811.277 Hydrolases 475
D08.811.277.040 Acid Anhydride Hydrolases 6
D08.811.277.040.600 Pyrophosphatases 24
D08.811.277.040.600.399 Inorganic Pyrophosphatase
D08.811.277.040.600.500 Inosine Triphosphatase
D08.811.277.040.600.600 Nudix Hydrolases
D08.811.277.040.600.600.500 Thiamine Pyrophosphatase 2
D09 Carbohydrates 724
D10 Lipids 2 535
D12 Amino Acids, Peptides, and Proteins 16
D13 Nucleic Acids, Nucleotides, and Nucleosides 9
D20 Complex Mixtures 19
D23 Biological Factors 143
D25 Biomedical and Dental Materials 111
D26 Pharmaceutical Preparations 7 071
D27 Chemical Actions and Uses 374

NPY1 protein, S cerevisiae Chemical MeSH Browser

NUDT10 protein, human Chemical MeSH Browser

NUDT11 protein, human Chemical MeSH Browser

NUDT12 protein, human Chemical MeSH Browser

NUDT15 protein, human Chemical MeSH Browser

NUDT2 protein, human Chemical MeSH Browser

NUDT7 protein, Arabidopsis Chemical MeSH Browser

NUDX19 protein, Arabidopsis Chemical MeSH Browser

NUDX7 protein, Arabidopsis Chemical MeSH Browser

Nudt19 protein, mouse Chemical MeSH Browser

Nudt7 protein, mouse Chemical MeSH Browser

Orf186 protein, E coli Chemical MeSH Browser

PCD1 protein, S cerevisiae Chemical MeSH Browser

nudix hydrolase Orf135 Chemical MeSH Browser

Back Add

Narrower terms