Degrons [degrony]

topical
Terms

C-degrony
destrukční box
destrukční boxy
motiv d-boxu
motiv destrukčního boxu
motiv PEST
N-degrony
sekvence PEST

 

C-Degrons
D-Box Motif
Destruction Box
Destruction Box Motif
Destruction Boxes
N-Degrons
PEST Motif
PEST Sequence

Persistent link   https://www.medvik.cz/link/D000097791
Definition

Minimal elements within a protein that are sufficient for recognition and degradation by a proteolytic apparatus. Inherent degrons are comprised of short linear amino acid sequences and secondary protein structural features that increase the affinity to E3 LIGASE; and are involved in regulating the specificity and timing of PROTEIN DEGRADATION. Acquired degrons are mostly transient and conferred by post-translational modifications of specific amino acids within proteins. (From Mol Cell. 2016 Sep 15;63(6):1055-65)

DUI
D000097791 MeSH Browser
CUI
M000764447
History note
2024
Public note
2024

Allowable subheadings

DE
drug effects
GE
genetics
IM
immunology
PH
physiology
RE
radiation effects

G Phenomena and Processes
G01 Physical Phenomena 81
G02 Chemical Phenomena 308
G02.111 Biochemical Phenomena 370
G02.111.570 Molecular Structure 1 339
G02.111.570.820 Molecular Conformation 228
G02.111.570.820.709 Protein Conformation 560
G02.111.570.820.709.275 Protein Structural Elements 1
G02.111.570.820.709.275.500 Amino Acid Motifs 101
G02.111.570.820.709.275.625 Degrons
G02.111.570.820.709.275.750 Protein Domains 180
G02.111.570.820.709.275.875 Repetitive Sequences, Amino Acid 4
G03 Metabolism 1 203
G03 Metabolic Phenomena obsolete
G04 Cell Physiological Phenomena 515
G05 Genetic Phenomena 135
G06 Microbiological Phenomena 96
G07 Physiological Phenomena 176
G08 Reproductive and Urinary Physiological Phenomena 18
G09 Circulatory and Respiratory Physiological Phenomena 93
G10 Digestive System and Oral Physiological Phenomena 4
G11 Musculoskeletal and Neural Physiological Phenomena 17
G12 Immune System Phenomena 249
G13 Integumentary System Physiological Phenomena 14
G14 Ocular Physiological Phenomena 148
G15 Plant Physiological Phenomena 158
G16 Biological Phenomena 130
G17 Mathematical Concepts 66

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