An alpha-globulin of about 453 amino acids, depending on the species. It is produced by the liver in response to lowered blood pressure and secreted into blood circulation. Angiotensinogen is the inactive precursor of the ANGIOTENSINS produced in the body by successive enzyme cleavages. Cleavage of angiotensinogen by RENIN yields the decapeptide ANGIOTENSIN I. Further cleavage of angiotensin I (by ANGIOTENSIN CONVERTING ENZYME) yields the potent vasoconstrictor octapeptide ANGIOTENSIN II; and then, via other enzymes, other angiotensins also involved in the hemodynamic-regulating RENIN-ANGIOTENSIN SYSTEM.

DUI

D000808 MeSH Browser

CUI

M0001208

CAS

Angiotensinogen (protein renin substrate)

Previous indexing

Alpha Globulins (1968-1974); Angiotensin II (1968-1974); Protein Precursors (1971-1974)

History note

87(75); was see under ANGIOTENSINS 1975-86

Public note

87; was see under ANGIOTENSINS 1975-86