A picolinic acid derivative isolated from various Fusarium species. It has been proposed for a variety of therapeutic applications but is primarily used as a research tool. Its mechanisms of action are poorly understood. It probably inhibits DOPAMINE BETA-HYDROXYLASE, the enzyme that converts dopamine to norepinephrine. It may also have other actions, including the inhibition of cell proliferation and DNA synthesis.

Annotation

/biosyn permitted if by organism

DUI

D005669 MeSH Browser

CUI

M0008907

CAS

2-Pyridinecarboxylic acid, 5-butyl-

Previous indexing

Picolinic Acids (1969-1974)

History note

91(75); was see under PICOLINIC ACIDS 1975-90

Public note

91; was see under PICOLINIC ACIDS 1975-90