An aldose-ketose isomerase that catalyzes the reversible interconversion of glucose 6-phosphate and fructose 6-phosphate. In prokaryotic and eukaryotic organisms it plays an essential role in glycolytic and gluconeogenic pathways. In mammalian systems the enzyme is found in the cytoplasm and as a secreted protein. This secreted form of glucose-6-phosphate isomerase has been referred to as autocrine motility factor or neuroleukin, and acts as a cytokine which binds to the AUTOCRINE MOTILITY FACTOR RECEPTOR. Deficiency of the enzyme in humans is an autosomal recessive trait, which results in CONGENITAL NONSPHEROCYTIC HEMOLYTIC ANEMIA.

DUI

D005956 MeSH Browser

CUI

M0009354

CAS

D-Glucose-6-phosphate ketol-isomerase

History note

1998(1965)

Public note

1998; see GLUCOSEPHOSPHATE ISOMERASE 1965-1997; for AUTOCRINE MOTILITY FACTOR see AUTOCRINE MOTILITY FACTOR 1992-2011; for NEUROLEUKIN see NEUROLEUKIN 1990-2011