Methylene cyclopropyl alanine and congeners isolated from the unripe edible fruit of the AKEE plant (BLIGHIA SAPIDA). Hypoglycin B is the gamma-glutamyl congener of hypoglycin A. They are very toxic and teratogenic, causing a syndrome called Jamaican vomiting sickness that includes a fall in blood glucose due to the interference of FATTY ACIDS and LEUCINE metabolism which leads to VOMITING, liver damage, CONVULSIONS and DEATH.

Annotation

Jamaican vomiting sickness : coordinate HYPOGLYCINS /pois (IM) with PLANT POISONING (IM)

DUI

D007005 MeSH Browser

CUI

M0010904

Previous indexing

Alanine (1973-1976); Cyclopropanes (1970-1976)

History note

91(77); was see under CYCLOPROPANES 1977-90

Public note

91; was see under CYCLOPROPANES 1977-90