An experimental animal model for the demyelinating disease of GUILLAINE-BARRE SYNDROME. In the most frequently used protocol, animals are injected with a peripheral nerve tissue protein homogenate. After approximately 2 weeks the animals develop a neuropathy secondary to a T cell-mediated autoimmune response directed towards the MYELIN P2 PROTEIN in peripheral nerves. Pathologic findings include a perivascular accumulation of macrophages and T lymphocytes in the peripheral nervous system, similar to that seen in the Guillaine-Barre syndrome. (From Adams et al., Principles of Neurology, 6th ed, p1314; J Neuroimmunol 1998 Apr 1;84(1):40-52)

Annotation

coordinate with GUILLAINE-BARRE SYNDROME if pertinent

DUI

D009444 MeSH Browser

CUI

M0014694

Previous indexing

Myelin Sheath (1966-1981); Neuritis (1966-1981); Peripheral Nerves (1966-1981)

History note

2005 (1982)

Public note

2005; see NEURITIS, EXPERIMENTAL ALLERGIC 1982-2004