A blood protein (NSILA) which mimics the biological activity of insulin in serum, but is not suppressed by insulin antibodies. During acid-ethanol extraction of Cohn fraction III, 10% of the activity is found in the supernatant (NSILA-S) and the remaining activity in the precipitate (NSILA-P). The latter is a large molecular compound, much less stable than the soluble fraction. NSILA-S is a more potent growth factor than insulin and exhibits sulfation activity.

Annotation

note category; a blood protein mimicking blood insulin

DUI

D009632 MeSH Browser

CUI

M0014953

Previous indexing

Blood Proteins (1966-1976); Insulin (1966-1976)

History note

77

Public note

77