A mixed-function oxygenase that catalyzes the hydroxylation of a prolyl-glycyl containing peptide, usually in PROTOCOLLAGEN, to a hydroxyprolylglycyl-containing-peptide. The enzyme utilizes molecular OXYGEN with a concomitant oxidative decarboxylation of 2-oxoglutarate to SUCCINATE. The enzyme occurs as a tetramer of two alpha and two beta subunits. The beta subunit of procollagen-proline dioxygenase is identical to the enzyme PROTEIN DISULFIDE-ISOMERASES.

DUI

D011393 MeSH Browser

CUI

M0017694

CAS

Procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase

Previous indexing

Hydroxylases (1966-1971)

History note

94; was PROLINE HYDROXYLASE 1972-93 (Prov 1972-73); PROLINE,2-OXOGLUTARATE 4-DIOXYGENASE was PROLINE,2-OXOGLUTARATE DIOXYGENASE see PROLINE HYDROXYLASE 1977-93

Online note

use PROCOLLAGEN-PROLINE DIOXYGENASE to search PROLINE HYDROXYLASE 1972-93 (as Prov 1972-73) & PROLINE,2-OXOGLUTARATE DIOXYGENASE 1977-93

Public note

94; was PROLINE HYDROXYLASE 1974-93; PROLINE,2-OXOGLUTARATE 4-DIOXYGENASE was PROLINE,2-OXOGLUTARATE DIOXYGENASE see PROLINE HYDROXYLASE 1977-93