Transglutaminases catalyze cross-linking of proteins at a GLUTAMINE in one chain with LYSINE in another chain. They include keratinocyte transglutaminase (TGM1 or TGK), tissue transglutaminase (TGM2 or TGC), plasma transglutaminase involved with coagulation (FACTOR XIII and FACTOR XIIIa), hair follicle transglutaminase, and prostate transglutaminase. Although structures differ, they share an active site (YGQCW) and strict CALCIUM dependence.

Annotation

distinguish entry terms GLUTAMINYL-PEPTIDE GAMMA-GLUTAMYLTRANSFERASES, and TRANSGLUTAMINASES from GAMMA-GLUTAMYL TRANSPEPTIDASE which is involved with glutathione metabolism; PLASMA TRANSGLUTAMINASE see FACTOR XIIIA is also available

DUI

D011503 MeSH Browser

CUI

M0017884

CAS

Protein-glutamine:amine gamma-glutamyltransferase

Previous indexing

Acyltransferases (1966-1985)

History note

2002(1986)

Public note

2002; see PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE 1986-2002; for TRANSGLUTAMINASES see TRANSGLUTAMINASES 1986-2002