Farnesyl-Diphosphate Farnesyltransferase [farnesyl-difosfofarnesyltransferasa]
- Terms
-
farnesyl-difosfofarnesyltransferáza
farnezyl-difosfofarnezyltransferáza
FPP-FPP-farnesyltransferasa
skvalensyntáza
skvalensyntetáza
skvalensynthasa
skvalensynthetasa
-
Farnesyldiphosphate-Farnesyldiphosphate Farnesyltransferase
FPP-FPP Farnesyl Transferase
Presqualene-Diphosphate Synthase
Squalene Synthase
Squalene Synthetase
The first committed enzyme of the biosynthesis pathway that leads to the production of STEROLS. it catalyzes the synthesis of SQUALENE from farnesyl pyrophosphate via the intermediate PRESQUALENE PYROPHOSPHATE. This enzyme is also a critical branch point enzyme in the biosynthesis of ISOPRENOIDS that is thought to regulate the flux of isoprene intermediates through the sterol pathway.
- DUI
- D013186 MeSH Browser
- CUI
- M0020401
- Previous indexing
- Pyrophosphoric Acids (1972-1974); Farnesol (1972-1974); Ligases (1972-1974); Squalene (1972-1974)
- History note
- 2006(1975)
- Public note
- 2006; see OXIDOREDUCTASES 1975-1990; FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE was indexed under OXIDOREDUCTASES & SQUALENE SYNTHETASE 1998-2001
Allowable subheadings
- AD
- administration & dosage
- AE
- adverse effects
- AN
- analysis
- AI
- antagonists & inhibitors 3
- BI
- biosynthesis
- BL
- blood
- CF
- cerebrospinal fluid
- CS
- chemical synthesis
- CH
- chemistry 1
- CL
- classification
- DF
- deficiency
- DE
- drug effects
- EC
- economics
- GE
- genetics 1
- HI
- history
- IM
- immunology
- IP
- isolation & purification
- ME
- metabolism 1
- PK
- pharmacokinetics
- PD
- pharmacology
- PH
- physiology
- PO
- poisoning
- RE
- radiation effects
- ST
- standards
- SD
- supply & distribution
- TU
- therapeutic use 1
- TO
- toxicity
- UL
- ultrastructure
- UR
- urine
CrtM protein, Staphylococcus aureus Chemical MeSH Browser
ERG9 protein, S cerevisiae Chemical MeSH Browser