Uncoupling Agents [rozpřahující látky]

topical
24
Terms

odpojovače

Persistent link   https://www.medvik.cz/link/D014475
Definition

Chemical agents that uncouple oxidation from phosphorylation in the metabolic cycle so that ATP synthesis does not occur. Included here are those IONOPHORES that disrupt electron transfer by short-circuiting the proton gradient across mitochondrial membranes.

Annotation
enzyme inhib
DUI
D014475 MeSH Browser
CUI
M0022252
Previous indexing
Oxidative Phosphorylation/drug effects (1966-1968); Oxidoreductases/antagonists & inhibitors (1968)
History note
72(69)
Public note
72; DIO-9 was see under ANTIBIOTICS 1975-81

Allowable subheadings

AD
administration & dosage
AE
adverse effects 1
AN
analysis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis 1
CH
chemistry 3
CL
classification 1
EC
economics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism 5
PK
pharmacokinetics
PD
pharmacology 11
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use 1
TO
toxicity 1
UR
urine

D Chemicals and Drugs
D01 Inorganic Chemicals 68
D02 Organic Chemicals 391
D03 Heterocyclic Compounds 189
D04 Polycyclic Compounds 65
D05 Macromolecular Substances 103
D06 Hormones, Hormone Substitutes, and Hormone Antagonists 43
D08 Enzymes and Coenzymes 7
D09 Carbohydrates 723
D10 Lipids 2 524
D12 Amino Acids, Peptides, and Proteins 16
D13 Nucleic Acids, Nucleotides, and Nucleosides 9
D20 Complex Mixtures 19
D23 Biological Factors 143
D25 Biomedical and Dental Materials 110
D26 Pharmaceutical Preparations 7 034
D27 Chemical Actions and Uses 374
D27.505 Pharmacologic Actions 408
D27.505.519 Molecular Mechanisms of Pharmacological Action 89
D27.505.519.389 Enzyme Inhibitors 873
D27.505.519.389.086 5-Lipoxygenase-Activating Protein Inhibitors 3
D27.505.519.389.089 Acetaldehyde Dehydrogenase Inhibitors 2
D27.505.519.389.092 Adenosine Deaminase Inhibitors 6
D27.505.519.389.108 Adenylyl Cyclase Inhibitors 14
D27.505.519.389.124 Aromatic Amino Acid Decarboxylase Inhibitors 8
D27.505.519.389.174 Calcineurin Inhibitors 122
D27.505.519.389.200 Carbonic Anhydrase Inhibitors 59
D27.505.519.389.237 Catechol O-Methyltransferase Inhibitors 31
D27.505.519.389.275 Cholinesterase Inhibitors 967
D27.505.519.389.310 Cyclooxygenase Inhibitors 454
D27.505.519.389.315 Gamma Secretase Inhibitors and Modulators
D27.505.519.389.320 Glycoside Hydrolase Inhibitors 47
D27.505.519.389.335 Cytochrome P-450 Enzyme Inhibitors 93
D27.505.519.389.350 Folic Acid Antagonists 67
D27.505.519.389.360 Histone Deacetylase Inhibitors 110
D27.505.519.389.370 Hydroxymethylglutaryl-CoA Reductase Inhibitors 1 837
D27.505.519.389.375 Integrase Inhibitors 4
D27.505.519.389.400 beta-Lactamase Inhibitors 74
D27.505.519.389.480 Lipoxygenase Inhibitors 51
D27.505.519.389.616 Monoamine Oxidase Inhibitors 155
D27.505.519.389.675 Nucleic Acid Synthesis Inhibitors 33
D27.505.519.389.705 Ornithine Decarboxylase Inhibitors 3
D27.505.519.389.735 Phosphodiesterase Inhibitors 405
D27.505.519.389.736 Phosphoinositide-3 Kinase Inhibitors 31
D27.505.519.389.737 Phospholipase A2 Inhibitors 9
D27.505.519.389.739 Poly(ADP-ribose) Polymerase Inhibitors 185
D27.505.519.389.740 Prolyl-Hydroxylase Inhibitors 3
D27.505.519.389.745 Protease Inhibitors 272
D27.505.519.389.755 Protein Kinase Inhibitors 1 364
D27.505.519.389.760 Protein Synthesis Inhibitors 37
D27.505.519.389.848 Proton Pump Inhibitors 489
D27.505.519.389.870 Steroid Synthesis Inhibitors 1
D27.505.519.389.892 Topoisomerase Inhibitors 7
D27.505.519.389.936 Uncoupling Agents 24
D27.505.519.389.936.500 Proton Ionophores 1

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