An antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids. It acts by interfering with the enzymatic steps involved in the conversion of acetate to hydroxymethylglutaryl coenzyme A as well as inhibiting the activity of HYDROXYMETHYLGLUTARYL COA REDUCTASES which is the rate limiting enzyme in the biosynthesis of cholesterol.

DUI

D015093 MeSH Browser

CUI

M0023214

CAS

Pentanedioic acid, 3-hydroxy-3-methyl-

Previous indexing

Antilipemic Agents (1966-1972); Anticholesteremic Agents (1966-1979); Glutarates (1966-1979); Hydroxy Acids (1975-1979)

History note

96; was 3-HYDROXY-3-METHYLGLUTARIC ACID 1980-95 (see under GLUTARATES 1980-90)

Public note

96; was 3-HYDROXY-3-METHYLGLUTARIC ACID 1980-95 (see under GLUTARATES 1980-90)