RNA, usually prepared by transcription from cloned DNA, which complements a specific mRNA or DNA and is generally used for studies of virus genes, distribution of specific RNA in tissues and cells, integration of viral DNA into genomes, transcription, etc. Whereas DNA PROBES are preferred for use at a more macroscopic level for detection of the presence of DNA/RNA from specific species or subspecies, RNA probes are preferred for genetic studies. Conventional labels for the RNA probe include radioisotope labels 32P and 125I and the chemical label biotin. RNA probes may be further divided by category into plus-sense RNA probes, minus-sense RNA probes, and antisense RNA probes.

Annotation

usually no qualif: /drug eff /ultrastruct permitted

DUI

D015347 MeSH Browser

CUI

M0023632

Previous indexing

Nucleic Acid Hybridization (1972-1988); RNA, Messenger (1972-1988)

History note

89

Public note

89