Vitamin K-dependent calcium-binding protein synthesized by OSTEOBLASTS and found primarily in BONES. Serum osteocalcin measurements provide a noninvasive specific marker of bone metabolism. The protein contains three residues of the amino acid gamma-carboxyglutamic acid (Gla), which, in the presence of CALCIUM, promotes binding to HYDROXYAPATITE and subsequent accumulation in BONE MATRIX.

DUI

D015675 MeSH Browser

CUI

M0024030

CAS

Osteocalcin (human reduced), 3-de-L-tyrosine-4-de-L-glutamine-5-de-L-tryptophan-6-de-L-leucine-9-L-serine-12-L-serine-19-L-threonine-22-L-glutamine-28-L-alanine-33-L-serine-35-L-glutamine-36-L-tyrosine-38-L-leucine-39-L-lysine-40-L-threonine-43-L-lysine-45-L-isoleucine-48-L-isoleucine-49-L-threonine-49a-L-isoleucine-

Previous indexing

Calcium-Binding Proteins (1980-1989); 1-Carboxyglutamic Acid (1978-1981); Binding Proteins (1978-1980); Calcium (1978-1980); Proteins (1980-1981)

History note

90; GLA-PROTEIN was see OSTEOCACLIN 1990-96

Online note

use OSTEOCALCIN to search GLA-PROTEIN 1990-96

Public note

90; GLA-PROTEIN was see OSTEOCALCIN 1990-96