Trans-acting nuclear proteins whose functional expression are required for retroviral replication. Specifically, the rev gene products are required for processing and translation of the gag and env mRNAs, and thus rev regulates the expression of the viral structural proteins. rev can also regulate viral regulatory proteins. A cis-acting antirepression sequence (CAR) in env, also known as the rev-responsive element (RRE), is responsive to the rev gene product. Rev is short for regulator of virion.

DUI

D015694 MeSH Browser

CUI

M0024072

Previous indexing

Retroviridae Proteins (1986-1989); Viral Proteins (1986-1989)

History note

91(90); was see under TRANS-ACTIVATORS 1990

Public note

91; was see under TRANS-ACTIVATORS 1990