A nuclear RNA-protein complex that plays a role in RNA processing. In the nucleoplasm, the U1 snRNP along with other small nuclear ribonucleoproteins (U2, U4-U6, and U5) assemble into SPLICEOSOMES that remove introns from pre-mRNA by splicing. The U1 snRNA forms base pairs with conserved sequence motifs at the 5'-splice site and recognizes both the 5'- and 3'-splice sites and may have a fundamental role in aligning the two sites for the splicing reaction.

DUI

D017412 MeSH Browser

CUI

M0026429

Previous indexing

Ribonucleoproteins (1975-1992)

History note

2000; U1 SNRNP was U1-RNP (SY) to SMALL RIBONUCLEOPROTEINS (NM) 1982-92

Public note

2000; RIBONUCLEOPROTEINS, SMALL, U1 was heading 1993-1999; U1-RNP was indexed under RIBONUCLEOPROTEINS 1982-92