High-molecular weight glycoproteins uniquely expressed on the surface of LEUKOCYTES and their hemopoietic progenitors. They contain two FIBRONECTIN TYPE III DOMAINS and possess cytoplasmic protein tyrosine phosphatase activity, which plays a role in intracellular signaling from the CELL SURFACE RECEPTORS. Leukocyte common antigens occur as multiple isoforms that result from alternative mRNA splicing and differential usage of three exons.

DUI

D017493 MeSH Browser

CUI

M0026536

Previous indexing

Antigens, CD (1989-1992); Antigens, Differentiation (1984-1991); Histocompatibility Antigens (1984-1992)

History note

2018 (1993); for RT7 use HISTOCOMPATIBILITY ANTIGENS RT 1983-92; for B220 ANTIGEN use ANTIGENS, CD45 1990-95

Public note

2018; see ANTIGENS, CD45 1993-2017 and CD45 ANTIGEN 1984-1992; CD45 ANTIGEN was indexed under ANTIGENS, CD 1989-92 and HISTOCOMPATIBILITY ANTIGENS & ANTIGENS, DIFFERENTIATION 1984-92; RT7 ANTIGEN was indexed under HISTOCOMPATIBILITY ANTIGENS 1983-92; B220 ANTIGEN was indexed under ANTIGENS, SURFACE 1990-95