Buthionine Sulfoximine [buthionin sulfoximin]
topical
8
Persistent link
https://www.medvik.cz/link/D019328
Definition
A synthetic amino acid that depletes glutathione by irreversibly inhibiting gamma-glutamylcysteine synthetase. Inhibition of this enzyme is a critical step in glutathione biosynthesis. It has been shown to inhibit the proliferative response in human T-lymphocytes and inhibit macrophage activation. (J Biol Chem 1995;270(33):1945-7)
- DUI
- D019328 MeSH Browser
- CUI
- M0028777
- CAS
- Butanoic acid, 2-amino-4-(S-butylsulfonimidoyl)-
- Previous indexing
- Methionine Sulfoximine (1979-1996)
- History note
- 97: was BUTHIONINE SULFOXIMINE (NM) 1979-96
- Online note
- use BUTHIONINE SULFOXIMINE (NM) to search BUTHIONINE SULFOXIMINE 1980-96
- Public note
- 97; BUTHIONINE SULFOXIMINE was indexed under METHIONINE SULFOXIMINE 1979-96
Allowable subheadings
- AD
- administration & dosage 1
- AE
- adverse effects
- AG
- agonists
- AA
- analogs & derivatives
- AN
- analysis
- AI
- antagonists & inhibitors
- BL
- blood
- CF
- cerebrospinal fluid
- CS
- chemical synthesis
- CH
- chemistry
- CL
- classification
- EC
- economics
- HI
- history
- IM
- immunology
- IP
- isolation & purification
- ME
- metabolism 1
- PK
- pharmacokinetics
- PD
- pharmacology 5
- PO
- poisoning
- RE
- radiation effects
- ST
- standards
- SD
- supply & distribution
- TU
- therapeutic use 1
- TO
- toxicity
- UR
- urine
...
Occurrences in Medvik records
D
Chemicals and Drugs