A widely used anti-inflammatory agent isolated from the licorice root. It is metabolized to GLYCYRRHETINIC ACID, which inhibits 11-BETA-HYDROXYSTEROID DEHYDROGENASES and other enzymes involved in the metabolism of CORTICOSTEROIDS. Therefore, glycyrrhizic acid, which is the main and sweet component of licorice, has been investigated for its ability to cause hypermineralocorticoidism with sodium retention and potassium loss, edema, increased blood pressure, as well as depression of the renin-angiotensin-aldosterone system.

Annotation

do not confuse with GLYCYRRHETINIC ACID

DUI

D019695 MeSH Browser

CUI

M0029245

CAS

alpha-D-glucopyranosiduronic acid, (3 beta,20 beta)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-beta-D-glucopyranuronosyl-

Previous indexing

Glycyrrhetinic Acid (1977-1997); Glycyrrhiza (1976-1985)

History note

98; see GLYCYRRHIZIC ACID (NM) 1976-97

Public note

98; GLYCYRRHIZIC ACID was indexed under GLYCYRRHETINIC ACID 1979-97, GLYCYRRHIZA 1976-79, GLUCOSIDURONATES 1976-79, & ENOXOLONE 1977-79