Calcineurin [kalcineurin]
- Terms
-
kalcineurin A
kalcineurin B
PP2B
proteinfosfatasa-2B
-
Calcineurin A
Calcineurin B
Protein Phosphatase 3
Protein Phosphatase 3 Catalytic Subunit
Protein Phosphatase 3 Regulatory Subunit
Protein Phosphatase-2B
A CALCIUM and CALMODULIN-dependent serine/threonine protein phosphatase that is composed of the calcineurin A catalytic subunit and the calcineurin B regulatory subunit. Calcineurin has been shown to dephosphorylate a number of phosphoproteins including HISTONES; MYOSIN LIGHT CHAIN; and the regulatory subunits of CAMP-DEPENDENT PROTEIN KINASES. It is involved in the regulation of signal transduction and is the target of an important class of immunophilin-immunosuppressive drug complexes.
- DUI
- D019703 MeSH Browser
- CUI
- M0029257
- Previous indexing
- Calcium-Binding Proteins (1986-1997); Calmodulin-Binding Proteins (1986-1997); Phosphoprotein Phosphatase (1988-1997)
- History note
- 98; see CALCINEURIN (NM) 1987-97
- Public note
- 98; CALCINEURIN was indexed under PHOSPHOPROTEIN PHOSPHATASE 1988-97 & CALMODULIN-BINDING PROTEINS 1986-97; CALCINEURIN B (now CALCINEURIN) was indexed under CALCIUM-BINDING PROTEINS 1994-97
Combination
- antagonists & inhibitors
- Calcineurin Inhibitors
Allowable subheadings
- AD
- administration & dosage 3
- AE
- adverse effects 7
- AN
- analysis 0
- BI
- biosynthesis 0
- BL
- blood 0
- CF
- cerebrospinal fluid 0
- CS
- chemical synthesis 0
- CH
- chemistry 1
- CL
- classification 0
- DF
- deficiency 0
- DE
- drug effects 1
- EC
- economics 0
- GE
- genetics 7
- HI
- history 0
- IM
- immunology 2
- IP
- isolation & purification 0
- ME
- metabolism 11
- PK
- pharmacokinetics 0
- PD
- pharmacology 11
- PH
- physiology 2
- PO
- poisoning 0
- RE
- radiation effects 0
- ST
- standards 0
- SD
- supply & distribution 0
- TU
- therapeutic use 20
- TO
- toxicity 1
- UL
- ultrastructure 0
- UR
- urine 0