Calcineurin [kalcineurin]

topical
76
Terms

kalcineurin A
kalcineurin B
PP2B
proteinfosfatasa-2B

 

Calcineurin A
Calcineurin B
Protein Phosphatase 3
Protein Phosphatase 3 Catalytic Subunit
Protein Phosphatase 3 Regulatory Subunit
Protein Phosphatase-2B

Persistent link   https://www.medvik.cz/link/D019703
Definition

A CALCIUM and CALMODULIN-dependent serine/threonine protein phosphatase that is composed of the calcineurin A catalytic subunit and the calcineurin B regulatory subunit. Calcineurin has been shown to dephosphorylate a number of phosphoproteins including HISTONES; MYOSIN LIGHT CHAIN; and the regulatory subunits of CAMP-DEPENDENT PROTEIN KINASES. It is involved in the regulation of signal transduction and is the target of an important class of immunophilin-immunosuppressive drug complexes.

DUI
D019703 MeSH Browser
CUI
M0029257
Previous indexing
Calcium-Binding Proteins (1986-1997); Calmodulin-Binding Proteins (1986-1997); Phosphoprotein Phosphatase (1988-1997)
History note
98; see CALCINEURIN (NM) 1987-97
Public note
98; CALCINEURIN was indexed under PHOSPHOPROTEIN PHOSPHATASE 1988-97 & CALMODULIN-BINDING PROTEINS 1986-97; CALCINEURIN B (now CALCINEURIN) was indexed under CALCIUM-BINDING PROTEINS 1994-97

Combination

antagonists & inhibitors
Calcineurin Inhibitors

Allowable subheadings

AD
administration & dosage 3
AE
adverse effects 7
AN
analysis
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry 1
CL
classification
DF
deficiency
DE
drug effects 1
EC
economics
GE
genetics 7
HI
history
IM
immunology 2
IP
isolation & purification
ME
metabolism 11
PK
pharmacokinetics
PD
pharmacology 11
PH
physiology 2
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use 20
TO
toxicity 1
UL
ultrastructure
UR
urine

D Chemicals and Drugs
D08 Enzymes and Coenzymes 7
D08.811 Enzymes 1 547
D08.811.277 Hydrolases 475
D08.811.277.352 Esterases 207
D08.811.277.352.650 Phosphoric Monoester Hydrolases 154
D08.811.277.352.650.625 Phosphoprotein Phosphatases 23
D08.811.277.352.650.625.150 Calcineurin 76
D08.811.277.352.650.625.225 Dual-Specificity Phosphatases 3
D08.811.277.352.650.625.300 Glycogen-Synthase-D Phosphatase
D08.811.277.352.650.625.475 Myosin-Light-Chain Phosphatase 2
D08.811.277.352.650.625.650 Phosphorylase Phosphatase
D08.811.277.352.650.625.687 Protein Phosphatase 1 5
D08.811.277.352.650.625.706 Protein Phosphatase 2 12
D08.811.277.352.650.625.716 Protein Phosphatase 2C 11
D08.811.277.352.650.625.725 Pyruvate Dehydrogenase (Lipoamide)-Phosphatase
D08.811.277.352.650.625.862 Tartrate-Resistant Acid Phosphatase 5
D12 Amino Acids, Peptides, and Proteins 16
D12.644 Peptides 1 382
D12.644.360 Intracellular Signaling Peptides and Proteins 174
D12.644.360.011 Activating Transcription Factor 6 3
D12.644.360.024 Adaptor Proteins, Signal Transducing 176
D12.644.360.075 Apoptosis Regulatory Proteins 78
D12.644.360.087 Calcineurin 76
D12.644.360.138 Circadian Rhythm Signaling Peptides and Proteins 11
D12.644.360.175 Cold Shock Proteins and Peptides 3
D12.644.360.225 Cyclin-Dependent Kinase Inhibitor Proteins 42
D12.644.360.262 Cyclins 112
D12.644.360.265 Disks Large Homolog 4 Protein 1
D12.644.360.325 GTP-Binding Protein Regulators 16
D12.644.360.365 I-kappa B Proteins 5
D12.644.360.368 Inhibitor of Growth Protein 1
D12.644.360.372 Intracellular Calcium-Sensing Proteins 2
D12.644.360.410 Mesothelin 2
D12.644.360.420 Methyl-Accepting Chemotaxis Proteins
D12.644.360.534 Mucin-4 5
D12.644.360.537 Myristoylated Alanine-Rich C Kinase Substrate
D12.644.360.539 NLR Proteins 4
D12.644.360.543 Olfactory Marker Protein
D12.644.360.562 Phosphatidylethanolamine Binding Protein
D12.644.360.606 Protein Phosphatase Inhibitory Proteins
D12.644.360.650 RNA-Binding Protein EWS 15
D12.644.360.700 SAP90-PSD95 Associated Proteins
D12.644.360.813 Secreted Frizzled-Related Proteins
D12.644.360.925 Tuberous Sclerosis Complex 1 Protein 7
D12.644.360.938 Tuberous Sclerosis Complex 2 Protein 9
D12.644.360.950 Tumor Necrosis Factor alpha-Induced Protein 3 1
D12.644.360.963 Tumor Protein, Translationally-Controlled 1
D12.776 Proteins 2 577
D12.776.476 Intracellular Signaling Peptides and Proteins 174
D12.776.476.559 Phosphoprotein Phosphatases 23
D12.776.476.559.150 Calcineurin 76
D12.776.476.559.225 Dual-Specificity Phosphatases 3
D12.776.476.559.300 Glycogen-Synthase-D Phosphatase
D12.776.476.559.475 Myosin-Light-Chain Phosphatase 2
D12.776.476.559.650 Phosphorylase Phosphatase
D12.776.476.559.687 Protein Phosphatase 1 5
D12.776.476.559.706 Protein Phosphatase 2 12
D12.776.476.559.716 Protein Phosphatase 2C 11
D12.776.476.559.725 Pyruvate Dehydrogenase (Lipoamide)-Phosphatase
D12.776.476.559.862 Tartrate-Resistant Acid Phosphatase 5

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