The joining of RNA from two different genes. One type of trans-splicing is the spliced leader type (primarily found in protozoans such as trypanosomes and in lower invertebrates such as nematodes) which results in the addition of a capped, noncoding, spliced leader sequence to the 5' end of mRNAs. Another type of trans-splicing is the discontinuous group II introns type (found in plant/algal chloroplasts and plant mitochondria) which results in the joining of two independently transcribed coding sequences. Both are mechanistically similar to conventional nuclear pre-mRNA cis-splicing. Mammalian cells are also capable of trans-splicing.

Annotation

note category: a physiol process taking place within the cell nucleus; do not confuse with DNA, RECOMBINANT; CLONING, MOLECULAR; or GENETIC ENGINEERING

DUI

D020040 MeSH Browser

CUI

M0029753

Previous indexing

RNA Splicing (1982-1998)

History note

1999

Public note

1999