Inhibitory Concentration 50 [inhibiční koncentrace 50]

topical
173
Terms

IC50

 

IC50

Persistent link   https://www.medvik.cz/link/D020128
Definition

The concentration of a compound needed to reduce population growth of organisms, including eukaryotic cells, by 50% in vitro. Though often expressed to denote in vitro antibacterial activity, it is also used as a benchmark for cytotoxicity to eukaryotic cells in culture.

Annotation
do not confuse with LETHAL DOSE 50, determined in animals
DUI
D020128 MeSH Browser
CUI
M0029868
Previous indexing
Cell Survival/drug effects (1971-1998)
History note
1999
Public note
1999

E Analytical, Diagnostic and Therapeutic Techniques and Equipment
E05 Investigative Techniques 209
E05.940 Toxicity Tests 408
E05.940.150 Carcinogenicity Tests 134
E05.940.245 Cytotoxicity Tests, Immunologic 321
E05.940.350 Inhibitory Concentration 50 173
E05.940.402 Lethal Dose 50 214
E05.940.481 Maximum Tolerated Dose 52
E05.940.560 Mutagenicity Tests 441
E05.940.600 No-Observed-Adverse-Effect Level 44
E05.940.790 Toxicity Tests, Acute 52
E05.940.800 Toxicity Tests, Chronic 17
E05.940.850 Toxicity Tests, Subacute 1
E05.940.900 Toxicity Tests, Subchronic 12

G Phenomena and Processes
G07 Physiological Phenomena 176
G07.690 Pharmacological and Toxicological Phenomena 59
G07.690.936 Toxicological Phenomena 4
G07.690.936.500 Dose-Response Relationship, Drug 2 366
G07.690.936.563 Inhibitory Concentration 50 173
G07.690.936.625 Maximum Tolerated Dose 52
G07.690.936.750 No-Observed-Adverse-Effect Level 44

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