ATP Binding Cassette Transporter, Subfamily B, Member 1 [P-glykoprotein]

topical
152
Terms

protein MDR1
protein vícečetné lékové rezistence 1

 

ABCB1 Protein
ATP Binding Cassette Transporter, Sub-Family B, Member 1
ATP-Binding Cassette, Sub-Family B, Member 1
ATP-Dependent Translocase ABCB1
CD243 Antigen
MDR1 Protein
MDR1B Protein
Multidrug Resistance Protein 1
P-Glycoprotein
P-Glycoprotein 1
PGY-1 Protein

Persistent link   https://www.medvik.cz/link/D020168
Definition

A 170-kDa transmembrane glycoprotein from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS. It serves as an ATP-dependent efflux pump for a variety of chemicals, including many ANTINEOPLASTIC AGENTS. Overexpression of this glycoprotein is associated with multidrug resistance (see DRUG RESISTANCE, MULTIPLE).

Annotation
note entry term: ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B is also available
DUI
D020168 MeSH Browser
CUI
M0029890
Previous indexing
P-Glycoprotein (1995-1998)
History note
2019 (1995)
Public note
2019; see ATP-BINDING CASSETTE, SUB-FAMILY B, MEMBER 1 2018; see P-GLYCOPROTEIN 1995-2017; ATP BINDING CASSETTE TRANSPORTER, SUB-FAMILY B, MEMBER 1 was indexed under P-GLYCOPROTEIN 1995-1998; under CARRIER PROTEINS & MEMBRANE GLYCOPROTEINS 1980-1994; under GLYCOPROTEINS 1980-1987; and under MEMBRANE PROTEINS 1980-1982

Allowable subheadings

AD
administration & dosage
AE
adverse effects 1
AG
agonists
AN
analysis 18
AI
antagonists & inhibitors 16
BI
biosynthesis 6
BL
blood 2
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry 3
CL
classification
DF
deficiency
DE
drug effects 22
EC
economics
GE
genetics 43
HI
history
IM
immunology 2
IP
isolation & purification
ME
metabolism 52
PK
pharmacokinetics 2
PD
pharmacology 3
PH
physiology 16
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use 2
TO
toxicity
UL
ultrastructure
UR
urine

D Chemicals and Drugs
D09 Carbohydrates 723
D09.400 Glycoconjugates 58
D09.400.430 Glycoproteins 637
D09.400.430.890 Membrane Glycoproteins 200
D09.400.430.890.020 ATP-Binding Cassette Transporters 168
D09.400.430.890.020.400 ATP Binding Cassette Transporter, Subfamily B 80
D09.400.430.890.020.400.153 ATP Binding Cassette Transporter, Subfamily B, Member 1 152
D09.400.430.890.020.400.305 ATP Binding Cassette Transporter, Subfamily B, Member 2 1
D09.400.430.890.020.400.458 ATP Binding Cassette Transporter, Subfamily B, Member 3 1
D09.400.430.890.020.400.534 ATP Binding Cassette Transporter, Subfamily B, Member 11 3
D09.400.430.890.020.400.767 ATP-Binding Cassette Sub-Family B Member 4 1
D12 Amino Acids, Peptides, and Proteins 16
D12.776 Proteins 2 577
D12.776.157 Carrier Proteins 546
D12.776.157.530 Membrane Transport Proteins 207
D12.776.157.530.100 ATP-Binding Cassette Transporters 168
D12.776.157.530.100.075 ATP Binding Cassette Transporter, Subfamily B 80
D12.776.157.530.100.075.063 ATP Binding Cassette Transporter, Subfamily B, Member 1 152
D12.776.157.530.100.075.125 ATP Binding Cassette Transporter, Subfamily B, Member 11 3
D12.776.157.530.100.075.250 ATP Binding Cassette Transporter, Subfamily B, Member 2 1
D12.776.157.530.100.075.500 ATP Binding Cassette Transporter, Subfamily B, Member 3 1
D12.776.157.530.100.075.750 ATP-Binding Cassette Sub-Family B Member 4 1
D12.776.157.530.450 Ion Pumps 25
D12.776.157.530.450.074 Anion Transport Proteins 9
D12.776.157.530.450.074.500 Organic Anion Transporters 42
D12.776.157.530.450.074.500.500 Organic Anion Transporters, ATP-Dependent
D12.776.157.530.450.074.500.500.250 ATP Binding Cassette Transporter, Subfamily B 80
D12.776.157.530.450.074.500.500.250.125 ATP Binding Cassette Transporter, Subfamily B, Member 1 152
D12.776.157.530.450.074.500.500.250.250 ATP Binding Cassette Transporter, Subfamily B, Member 2 1
D12.776.157.530.450.074.500.500.250.375 ATP Binding Cassette Transporter, Subfamily B, Member 3 1
D12.776.157.530.450.074.500.500.250.438 ATP Binding Cassette Transporter, Subfamily B, Member 11 3
D12.776.157.530.450.074.500.500.250.719 ATP-Binding Cassette Sub-Family B Member 4 1
D12.776.395 Glycoproteins 637
D12.776.395.550 Membrane Glycoproteins 200
D12.776.395.550.020 ATP-Binding Cassette Transporters 168
D12.776.395.550.020.400 ATP Binding Cassette Transporter, Subfamily B 80
D12.776.395.550.020.400.153 ATP Binding Cassette Transporter, Subfamily B, Member 1 152
D12.776.395.550.020.400.305 ATP Binding Cassette Transporter, Subfamily B, Member 2 1
D12.776.395.550.020.400.458 ATP Binding Cassette Transporter, Subfamily B, Member 3 1
D12.776.395.550.020.400.534 ATP Binding Cassette Transporter, Subfamily B, Member 11 3
D12.776.395.550.020.400.767 ATP-Binding Cassette Sub-Family B Member 4 1
D12.776.543 Membrane Proteins 849
D12.776.543.550 Membrane Glycoproteins 200
D12.776.543.550.192 ATP-Binding Cassette Transporters 168
D12.776.543.550.192.400 ATP Binding Cassette Transporter, Subfamily B 80
D12.776.543.550.192.400.153 ATP Binding Cassette Transporter, Subfamily B, Member 1 152
D12.776.543.550.192.400.305 ATP Binding Cassette Transporter, Subfamily B, Member 2 1
D12.776.543.550.192.400.458 ATP Binding Cassette Transporter, Subfamily B, Member 3 1
D12.776.543.550.192.400.534 ATP Binding Cassette Transporter, Subfamily B, Member 11 3
D12.776.543.550.192.400.767 ATP-Binding Cassette Sub-Family B Member 4 1
D12.776.543.585 Membrane Transport Proteins 207
D12.776.543.585.100 ATP-Binding Cassette Transporters 168
D12.776.543.585.100.200 ATP Binding Cassette Transporter, Subfamily B 80
D12.776.543.585.100.200.125 ATP Binding Cassette Transporter, Subfamily B, Member 1 152
D12.776.543.585.100.200.250 ATP Binding Cassette Transporter, Subfamily B, Member 2 1
D12.776.543.585.100.200.375 ATP Binding Cassette Transporter, Subfamily B, Member 3 1
D12.776.543.585.100.200.438 ATP Binding Cassette Transporter, Subfamily B, Member 11 3
D12.776.543.585.100.200.719 ATP-Binding Cassette Sub-Family B Member 4 1
D12.776.543.585.450 Ion Pumps 25
D12.776.543.585.450.074 Anion Transport Proteins 9
D12.776.543.585.450.074.500 Organic Anion Transporters 42
D12.776.543.585.450.074.500.500 Organic Anion Transporters, ATP-Dependent
D12.776.543.585.450.074.500.500.250 ATP Binding Cassette Transporter, Subfamily B 80
D12.776.543.585.450.074.500.500.250.125 ATP Binding Cassette Transporter, Subfamily B, Member 1 152
D12.776.543.585.450.074.500.500.250.250 ATP Binding Cassette Transporter, Subfamily B, Member 2 1
D12.776.543.585.450.074.500.500.250.375 ATP Binding Cassette Transporter, Subfamily B, Member 3 1
D12.776.543.585.450.074.500.500.250.438 ATP Binding Cassette Transporter, Subfamily B, Member 11 3
D12.776.543.585.450.074.500.500.250.719 ATP-Binding Cassette Sub-Family B Member 4 1

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