Caspases [kaspasy]

topical
158
Terms

kaspázy

 

Caspase

Persistent link   https://www.medvik.cz/link/D020169
Definition

A family of intracellular CYSTEINE ENDOPEPTIDASES that play a role in regulating INFLAMMATION and APOPTOSIS. They specifically cleave peptides at a CYSTEINE amino acid that follows an ASPARTIC ACID residue. Caspases are activated by proteolytic cleavage of a precursor form to yield large and small subunits that form the enzyme. Since the cleavage site within precursors matches the specificity of caspases, sequential activation of precursors by activated caspases can occur.

Annotation
CASPASES, EFFECTOR and CASPASES, INITIATOR and specifics are available
DUI
D020169 MeSH Browser
CUI
M0029891
Previous indexing
Cysteine Proteinases (1997-1998)
History note
1999
Public note
1999

Combination

antagonists & inhibitors
Caspase Inhibitors

Allowable subheadings

AD
administration & dosage 1
AE
adverse effects 1
AN
analysis 8
BI
biosynthesis 1
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry 7
CL
classification 2
DF
deficiency 1
DE
drug effects 10
EC
economics
GE
genetics 15
HI
history
IM
immunology 5
IP
isolation & purification 1
ME
metabolism 88
PK
pharmacokinetics 1
PD
pharmacology 6
PH
physiology 21
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine

D Chemicals and Drugs
D08 Enzymes and Coenzymes 7
D08.811 Enzymes 1 551
D08.811.277 Hydrolases 475
D08.811.277.656 Peptide Hydrolases 560
D08.811.277.656.262 Cysteine Proteases 12
D08.811.277.656.262.500 Cysteine Endopeptidases 44
D08.811.277.656.262.500.096 Bromelains 37
D08.811.277.656.262.500.108 3C Viral Proteases 1
D08.811.277.656.262.500.120 Calpain 23
D08.811.277.656.262.500.126 Caspases 158
D08.811.277.656.262.500.126.350 Caspases, Effector 1
D08.811.277.656.262.500.126.550 Caspases, Initiator 3
D08.811.277.656.262.500.126.775 Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein 1
D08.811.277.656.262.500.133 Cathepsin B 46
D08.811.277.656.262.500.146 Cathepsin F
D08.811.277.656.262.500.153 Cathepsin H 1
D08.811.277.656.262.500.156 Cathepsin K 13
D08.811.277.656.262.500.157 Cathepsin L 11
D08.811.277.656.262.500.158 Cathepsin W
D08.811.277.656.262.500.160 Chymopapain
D08.811.277.656.262.500.350 Ficain
D08.811.277.656.262.500.468 Gingipain Cysteine Endopeptidases
D08.811.277.656.262.500.585 Papain 39
D08.811.277.656.262.500.792 Separase 1
D08.811.277.656.262.500.896 Viral Papain-like Proteases
D08.811.277.656.300 Endopeptidases 211
D08.811.277.656.300.200 Cysteine Endopeptidases 44
D08.811.277.656.300.200.096 Bromelains 37
D08.811.277.656.300.200.120 Calpain 23
D08.811.277.656.300.200.126 Caspases 158
D08.811.277.656.300.200.126.350 Caspases, Effector 1
D08.811.277.656.300.200.126.550 Caspases, Initiator 3
D08.811.277.656.300.200.126.775 Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein 1
D08.811.277.656.300.200.133 Cathepsin B 46
D08.811.277.656.300.200.146 Cathepsin F
D08.811.277.656.300.200.153 Cathepsin H 1
D08.811.277.656.300.200.156 Cathepsin K 13
D08.811.277.656.300.200.157 Cathepsin L 11
D08.811.277.656.300.200.158 Cathepsin W
D08.811.277.656.300.200.160 Chymopapain
D08.811.277.656.300.200.350 Ficain
D08.811.277.656.300.200.585 Papain 39
D08.811.277.656.300.200.792 Separase 1
D12 Amino Acids, Peptides, and Proteins 16
D12.776 Proteins 2 581
D12.776.476 Intracellular Signaling Peptides and Proteins 175
D12.776.476.075 Apoptosis Regulatory Proteins 79
D12.776.476.075.311 Apoptosis Inducing Factor 10
D12.776.476.075.323 Bcl-2-Like Protein 11 5
D12.776.476.075.335 Beclin-1 3
D12.776.476.075.358 CARD Signaling Adaptor Proteins 7
D12.776.476.075.405 Caspases 158
D12.776.476.075.405.350 Caspases, Effector 1
D12.776.476.075.405.550 Caspases, Initiator 3
D12.776.476.075.413 DCC Receptor
D12.776.476.075.421 Death Domain Receptor Signaling Adaptor Proteins 5
D12.776.476.075.429 High-Temperature Requirement A Serine Peptidase 2
D12.776.476.075.437 Inhibitor of Apoptosis Proteins 29
D12.776.476.075.718 Proto-Oncogene Proteins c-bcl-2 148

CASP14 protein, human Chemical MeSH Browser

CASP5 protein, human Chemical MeSH Browser

Casp14 protein, mouse Chemical MeSH Browser

Casp4 protein, rat Chemical MeSH Browser

DAMM protein, Drosophila Chemical MeSH Browser

Dcp-1 protein, Drosophila Chemical MeSH Browser

MC1 protein, Arabidopsis Chemical MeSH Browser

MC2 protein, Arabidopsis Chemical MeSH Browser

MCA1 protein, S cerevisiae Chemical MeSH Browser

Mca1 protein, S pombe Chemical MeSH Browser

STRICA protein, Drosophila Chemical MeSH Browser

caspa protein, zebrafish Chemical MeSH Browser

caspase 11, human Chemical MeSH Browser

caspase 13 Chemical MeSH Browser

caspase 32, rat Chemical MeSH Browser

caspase 9s, human Chemical MeSH Browser

caspb protein, zebrafish Chemical MeSH Browser

ced-3 protein, C elegans Chemical MeSH Browser

csp-1 protein, C elegans Chemical MeSH Browser

csp-3 protein, C elegans Chemical MeSH Browser

decay protein, Drosophila Chemical MeSH Browser

drICE protein, Drosophila Chemical MeSH Browser

dredd protein, Drosophila Chemical MeSH Browser

dronc protein, Drosophila Chemical MeSH Browser

metacaspase 9, Arabidopsis Chemical MeSH Browser

type II metacaspase, tomato Chemical MeSH Browser

Add

Narrower terms