RNA, Small Interfering [malá interferující RNA]
- Terms
-
krátká interferující RNA
krátká vlásenková RNA
malá scanRNA
malá vlásenková RNA
rasiRNA
RNA malá interferující
scanRNA
scnRNA
shRNA
siRNA
tasiRNA
trans-působící siRNA
-
Repeat-Associated siRNA
RNA, Scan
Scan RNA
scnRNA
Short Hairpin RNA
Short Interfering RNA
shRNA
siRNA
siRNA, Repeat-Associated
siRNA, Trans-Acting
Small Hairpin RNA
Small Interfering RNA
Small Scan RNA
tasiRNA
Trans-Acting siRNA
Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.
- Annotation
- Do not confuse with defective interfering RNA (diRNA), a viral RNA of DEFECTIVE VIRUSES.
- DUI
- D034741 MeSH Browser
- CUI
- M0406100
- History note
- 2003; use RNA, SMALL INTERFERING (NM) 2001-2002
- Public note
- 2003; RNA, SMALL INTERFERING was indexed under RNA, UNTRANSLATED 2001-2002
Allowable subheadings
- AD
- administration & dosage 20
- AE
- adverse effects 2
- AG
- agonists
- AN
- analysis 2
- AI
- antagonists & inhibitors
- BI
- biosynthesis 1
- BL
- blood 1
- CF
- cerebrospinal fluid
- CS
- chemical synthesis
- CH
- chemistry 10
- CL
- classification
- DE
- drug effects 1
- EC
- economics 2
- GE
- genetics 92
- HI
- history
- IM
- immunology 2
- IP
- isolation & purification 1
- ME
- metabolism 64
- PK
- pharmacokinetics 1
- PD
- pharmacology 30
- PH
- physiology 5
- PO
- poisoning
- RE
- radiation effects
- ST
- standards
- SD
- supply & distribution
- TU
- therapeutic use 39
- TO
- toxicity
- UL
- ultrastructure 1
- UR
- urine 1
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