MicroRNAs [mikro RNA]
- Terms
-
malá dočasná RNA
mikroRNA
miRNA
pre-miRNA
pri-miRNA
primární mikro RNA
primární mikroRNA
primární miRNA
RNA malá přechodná
stRNA
-
Micro RNA
MicroRNA
miRNA
miRNAs
pre-miRNA
pri-miRNA
Primary MicroRNA
Primary miRNA
RNA, Small Temporal
Small Temporal RNA
stRNA
Small double-stranded, non-protein coding RNAs, 21-25 nucleotides in length generated from single-stranded microRNA gene transcripts by the same RIBONUCLEASE III, Dicer, that produces small interfering RNAs (RNA, SMALL INTERFERING). They become part of the RNA-INDUCED SILENCING COMPLEX and repress the translation (TRANSLATION, GENETIC) of target RNA by binding to homologous 3'UTR region as an imperfect match. The small temporal RNAs (stRNAs), let-7 and lin-4, from C. elegans, are the first 2 miRNAs discovered, and are from a class of miRNAs involved in developmental timing.
- DUI
- D035683 MeSH Browser
- CUI
- M0407989
- Previous indexing
- RNA, Antisense (2001-2002); RNA, Untranslated (2001-2002)
- History note
- 2003; use MICRORNAS (NM) 2001-2002
- Public note
- 2003; MICRORNAS was indexed under RNA, UNTRANSLATED and RNA, ANTISENSE 2001-2002
Allowable subheadings
- AD
- administration & dosage 5
- AE
- adverse effects 4
- AG
- agonists 0
- AN
- analysis 80
- AI
- antagonists & inhibitors 7
- BI
- biosynthesis 44
- BL
- blood 80
- CF
- cerebrospinal fluid 1
- CS
- chemical synthesis 0
- CH
- chemistry 6
- CL
- classification 9
- DE
- drug effects 13
- EC
- economics 0
- GE
- genetics 444
- HI
- history 0
- IM
- immunology 8
- IP
- isolation & purification 14
- ME
- metabolism 198
- PK
- pharmacokinetics 0
- PD
- pharmacology 6
- PH
- physiology 37
- PO
- poisoning 0
- RE
- radiation effects 1
- ST
- standards 0
- SD
- supply & distribution 0
- TU
- therapeutic use 16
- TO
- toxicity 0
- UL
- ultrastructure 0
- UR
- urine 11