A multifunctional protein that is found primarily within membrane-bound organelles. In the ENDOPLASMIC RETICULUM it binds to specific N-linked oligosaccharides found on newly-synthesized proteins and functions as a MOLECULAR CHAPERONE that may play a role in PROTEIN FOLDING or retention and degradation of misfolded proteins. In addition calreticulin is a major storage form for CALCIUM and functions as a calcium-signaling molecule that can regulate intracellular calcium HOMEOSTASIS.

DUI

D037282 MeSH Prohlížeč

CUI

M0172278

Předchozí užití

Calcium-Binding Proteins (1990-2002)

Historická pozn.

2003; use CALRETICULIN (NM) 1990-2002

Veřejná pozn.

2003; CALRETICULIN was indexed under CALCIUM-BINDING PROTEINS 1990-2002