A 10.8-kDa member of the S-100 family of calcium-binding proteins that can form homo- or heterocomplexes with CALGRANULIN B and a variety of other proteins. The calgranulin A/B heterodimer is known as LEUKOCYTE L1 ANTIGEN COMPLEX. Calgranulin A is found in many cell types including GRANULOCYTES; KERATINOCYTES; and myelomonocytes, and has been shown to act as a chemotactic substance for NEUTROPHILS. Because it is present in acute inflammation but absent in chronic inflammation, it is a useful biological marker for a number of pathological conditions.

DUI

D040501 MeSH Browser

CUI

M0169795

Previous indexing

Calcium-Binding Proteins (1989-2002); Antigens, Differentiation (1989-2002)

History note

2003; use CALGRANULIN A (NM) 1998-2002;

Public note

2003; CALGRANULIN A was indexed under CALCIUM-BINDING BINDING PROTEINS 1989-2002; MRP-8 PROTEIN (now CALGRANULIN A) was indexed under ANTIGENS, DIFFERENTIATION & CALCIUM-BINDING PROTEINS 1989-2002