A phosphorus-oxygen lyase found primarily in BACTERIA. The enzyme catalyzes the cleavage of a phosphoester linkage in 1-phosphatidyl-1D-myo-inositol to form 1D-myo-inositol 1,2-cyclic phosphate and diacylglycerol. The enzyme was formerly classified as a phosphoric diester hydrolase (EC 3.1.4.10) and is often referred to as a TYPE C PHOSPHOLIPASES. However it is now known that a cyclic phosphate is the final product of this enzyme and that water does not enter into the reaction.

Annotation

note X refs: TYPE C PHOSPHOLIPASES is also available

DUI

D043265 MeSH Browser

CUI

M0077159

Previous indexing

Phosphatidylinositols (1977-1982); Phospholipase C (1998-2003); Phosphoric Diester Hydrolases (1976-1997)

History note

2004; use PHOSPHOTIDYLINOSITOL DIACYLGLYCEROL-LYASE (NM) 1980-2003

Public note

2004; 1-PHOSPHATYDYLINOSITOL-GLYCAN-SPECIFIC PHOSPHOLIPASE C (now PHOSPHATIDYLINOSITOL DIACYLGLYCEROL-LYASE) was indexed under PHOSPHOLIPASE C 1998-2003; under PHOSPHORIC DIESTER HYDROLASES 1976-1997 & under PHOSPHATIDYLINOSITOLS 1977-1982